25220-22-8

Upstream product

• 38828-29-4 α-benzoyloxy-4-methoxy-deoxybenzoin 
• 532-32-1 sodium benzoate 
• 1369425-79-5 2-(4-methoxyphenyl)-3-phenylazacyclopropene 
• 100-52-7 benzaldehyde 
• 10374-18-2 N-[(4-methoxyphenyl)methylidene]benzamide 
• 98-88-4 benzoyl chloride 
• 1889-77-6 2-bromo-1-(4-methoxy-phenyl)-2-phenyl-ethanone 

Downstream Products

• 84671-89-6 2-[4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-2-methyl-propionic acid ethyl ester 
• 84671-90-9 2-[4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-propionic acid ethyl ester 
• 84671-91-0 [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester 
• 84672-06-0 2-[4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-2-methyl-propionic acid 
• 84672-07-1 [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid 
• 84672-24-2 4-(2,5-diphenyl-oxazol-4-yl)-phenol 

Relevant academic research and scientific papers

A Divergent Approach to Indoles and Oxazoles from Enamides by Directing-Group-Controlled Cu-Catalyzed Intramolecular C-H Amination and Alkoxylation

A directing-group-controlled, copper-catalyzed divergent approach to indoles and oxazoles from enamides has been developed. The picolinamide-derived enamides undergo the intramolecular aromatic C-H amination in the presence of a Cu(OPiv)2 catalyst and an MnO2 oxidant to form the corresponding indoles in good yields. On the other hand, simpler aryl- or alkyl-substituted enamides are converted to the 2,4,5-trisubstituted oxazole frameworks via vinylic C-H alkoxylation under identical conditions. The copper catalysis can provide uniquely divergent access to indole and oxazole heteroaromatic cores of great importance in medicinal and material chemistry.

[3 + 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2H-Azirines and Aldehydes

A novel [3 + 2] cycloaddition/oxidative aromatization sequence via visible light-induced photoredox catalysis is disclosed. It provides a general synthetic route to 2,4,5-trisubstituted oxazoles from easily accessible 2H-azirines and aldehydes under mild reaction conditions. The potential of this strategy was further demonstrated by the rapid synthesis of a cyclooxygenase-2 inhibitor as well as the success of employing electron-deficient alkenes and imines as the reaction partners.

An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions

Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric oxazoles.

Potential Hypolipidemic Agents: Part I-Synthesis and Hypolipidemic Activity of Some 4-(2,5-Substituted oxazole-4-yl)phenoxyalkanoic Acid Derivatives

A series of 4-(2-aryl-5-alkyl-aryloxazol-4-yl)phenoxyalkanoic acid derivatives (VI, 1-32) have been synthesised by O-alkylation of the corresponding 2-aryl-4-(4-hydroxyphenyl)-5-alkyl/aryloxazoles (Va-g) and evaluated for their hypolipidemic activity in rats of Wistar strain.Several compounds in this series show hypolipidemic activity comparable with that of the standard drug clofibrate at 200 mg/kg (p.o) dose.