2524-69-8

Upstream product

• 456-49-5 1-fluoro-3-methoxybenzene 
• 109-89-7 diethylamine 
• 372-18-9 1,3-Difluorobenzene 
• 540-36-3 para-difluorobenzene 
• 367-11-3 ortho-difluorobenzene 
• 1073-06-9 3-fluorobromobenzene 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 462-06-6 fluorobenzene 

Relevant academic research and scientific papers

Salt and dye

Provided is a salt, containing N-valent organic metal negative ion Mn- capable of forming metal atom of the bivalent-plus metal ion and Weng cationic capable of forming salt dyes with the organic metal negative ion. When the organic metal negative ion is the compound indicated in the formula (1) that meets specific requirements. The solvent performance of the salt in the organic solution is excellent.

Amination of aryl bromides catalysed by supported palladium

Palladium particles immobilised onto a metal oxide support or Pd(0), Pd(II) and [Pd(NH3)4]2+ in NaY zeolite have been prepared and characterised. They exhibit a good activity towards the amination of aryl bromides using secondary amines such as piperidine and diethyl amine with a good regio-selectivity for these reactions. Low Pd concentrations (1 mol%) are required to observe a reasonable regio-selectivity. The catalysts can easily be separated from the reaction mixture (filtration) and reused without loss of activity and selectivity. The electronic nature of the aryl halides plays an important role for both the reaction yields and the regio-control of the reaction. It depends on the relation of the direct amination via a benzyne intermediate versus the Pd-catalysed route.

Photochemical Reactions of Substituted Benzenes with Aliphatic Amines

The products arising from the irradiation of diethylamine and t-butylamine with toluene, chlorobenzene, anisole, benzonitrile, benzyl fluoride, benzotrifluoride (α,α,α-trifluorotoluene), m-fluorobenzotrifluoride (α,α,α,m-tetrafluorotoluene), p-fluorotoluene, m-fluorotoluene, p-fluoroanisole, m-fluoroanisole, and 1,3-bis(trifluoromethyl)benzene, and of triethylamine with toluene, benzotrifluoride and 1,3-bis(trifluoromethyl)benzene, all at 254 nm, are described.Reaction pathways involving both substitution and 1,2- and 1,4-acyclic addition processes are observed and which predominates depends upon the arene substituent.The novel acyclic adduct, Me2C=CH-CH=CH-CH=NBut, is obtained from toluene and t-butylamine and, contrary to previous reports, chlorobenzene yields arene-amine 1:1 adducts as well as the amine α-substitution product (16); benzonitrile gives aniline derivatives with the primary and secondary amines.

Exited State Substitution and Addition Reactions of Aryl Fluorides with Aliphatic Amines

Fluorobenzene and the difluorobenzenes undergo photochemical reaction with t-butylamine and diethylamine to give both 1:1 adducts and substitution products but only the latter are formed from hexafluorobenzene and diethylamine.Both cine and 'normal' substitution products are observed from the difluoro-compounds and the mechanism to account for this is considered to involve a polar excited-state complex between the addends and an addition-elimination process rather than benzyne intermediates. 1,2-Acyclic amine photoadducts are produced from most systems but the corresponding 1,4-isomers are the major adducts from p-difluorobenzene and that from diethylamine is unique in undergoing thermal retro-addition to the starting materials rather than conversion into the aniline derivative.