25290-19-1

Upstream product

• 14230-31-0 1-triethylstannanyl-propan-2-one 
• 104-55-2 3-phenyl-propenal 
• 58369-46-3 6-phenyl-5-hexene-2,4-dione 
• 14371-10-9 (E)-3-phenylpropenal 
• 78-95-5 chloroacetone 
• 598-31-2 1-bromoacetone 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 67-64-1 acetone 

Relevant academic research and scientific papers

Ionic liquid catalysed synthesis of β-hydroxy ketones

Different acidic ionic liquids (ILs; namely, 1-methylimidazolium tetrafluoroborate, 1-methylimidazolium trifluoroacetate, N-methyl-2-pyrrolidone hydrogen sulfate, N,N,N-trioctyl-n-butanesulfonic acid ammonium hydrogen sulfate, 1-methyl-3-(3-sulfobutyl)imidazolium hydrogen sulfate) and basic ILs (namely, 1,1,3,3-tetramethylguanidinium lactate and choline hydroxide) were tested as catalysts for the aldol reaction. The choline hydroxide catalysed reaction gave high yield (94.3%) and selectivity of the 4-hydroxy-4-phenylbutan- 2-one after a short reaction time (15min) at 0°C. This article demonstrates the potential of choline hydroxide, which is a derivative of choline and a naturally occurring water-soluble essential nutrient, as a highly active and selective green catalyst.

Zr(OtBu)4-catalysed synthesis of acetone aldol adducts and domino aldol-Tishchenko reactions with diacetone alcohol as enol equivalent

Zr(OtBu)4 was found to be a potent catalyst for the synthesis of acetone aldol adducts with diacetone alcohol as enol equivalent and for domino aldol-Tishchenko reaction giving rise to 1,3-anti-diol monoesters with excellent diastereoselectivity.

Reaction of α-Halogeno Ketones with Carbonyl Compounds Promoted by CeI3, CeCl3-NaI,or CeCl3-SnCl2

Reaction of α-halogeno ketones with aldehydes in the presence of CeI3 in tetrahydrofuran is found to give α,β-unsaturated ketones in excellent yields under mild conditions.In contrast, treatment of α-halogeno ketones and carbonyl compounds with CeCl3-NaI or CeCl3-SnCl2 affords β-hydroxy ketones in good yields.It is assumed that these reactions proceed via cerium enolates.The combined reagents, however, cannot be applied to a Reformatsky-type reaction.Regiospecific and aldehyde chemoselective aldol synthesis are also described.

BOROHYDRIDE REDUCING AGENT DERIVED FROM ANION EXCHANGE RESIN : SELECTIVE REDUCTION OF α, β-UNSATURATED CARBONYL COMPOUNDS.

Borohydride exchange resin (BER) exhibited selectivity in the reduction of α, β-unsaturated carbonyl compounds to the corresponding unsaturated alcohols.