58369-46-3Relevant articles and documents
Synthesis of 5-cinnamoyl-3,4-dihydropyrimidine-2(1H)-ones
Kolosov, Maksim A.,Kulyk, Olesia G.,Shvets, Elena H.,Orlov, Valeriy D.
, p. 1649 - 1657 (2014/06/09)
Two different approaches to the synthesis of 1-unsubstituted 5-cinnamoyl-3,4-dihydropyrimidine-2(1H)-ones have been developed. The first includes N(1)-protection of the starting 5-acetyl-3,4-dihydropyrimidine-2(1H)- one, further Claisen-Schmidt reaction,
Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1
Konno, Hiroyuki,Endo, Hitoshi,Ise, Satomi,Miyazaki, Keiki,Aoki, Hideo,Sanjoh, Akira,Kobayashi, Kazuya,Hattori, Yasunao,Akaji, Kenichi
supporting information, p. 685 - 690 (2014/01/23)
To research a new non-peptidyl inhibitor of beta-site amyloid precursor protein cleaving enzyme 1, we focused on the curcumin framework, two phenolic groups combined with an sp2 carbon spacer for low-molecular and high lipophilicity. The structure-activity relationship study of curcumin derivatives is described. Our results indicate that phenolic hydroxy groups and an alkenyl spacer are important structural factors for the inhibition of beta-site amyloid precursor protein cleaving enzyme 1 and, furthermore, non-competitive inhibition of enzyme activity is anticipated from an inhibitory kinetics experiment and docking simulation.
Metal chelates of 6-aryl-5-hexene-2,4-diones
Venugopalan,Krishnankutty
, p. 472 - 473 (2007/10/03)
A series of 6-aryl-5-hexene-2,4-diones and their NiII, CuII, ZnII and PdII chelates of composition ML2 have been synthesised. The metal ion replaces the enol proton of the ligands with the formation o