25291-41-2

Basic information

• Product Name: N-Acetylcyclopentane-1-amine
• Synonyms: N-Acetylcyclopentane-1-amine;N-Cyclopentylacetamide
• CAS NO: 25291-41-2
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.18
• Mol File: 25291-41-2.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Acetylcyclopentane-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetylcyclopentane-1-amine(25291-41-2)
• EPA Substance Registry System: N-Acetylcyclopentane-1-amine(25291-41-2)

Safety Data

• Hazardous Substances Data: 25291-41-2(Hazardous Substances Data)

Usage

Uses

N-?Cyclopentylacetamide is a derivative of 3-?Oxobutanenitrile (O869928) a reagent used in the synthesis of pyrazolopyrimidinones as well as in the preparation of inhibitors of phosphopantetheine.

Upstream product

• 74-90-8 hydrogen cyanide 
• 3400-45-1 cyclopentanecarboxylic acid 
• 140-11-4 Benzyl acetate 
• 1003-03-8 Cyclopentamine 
• 108-22-5 Isopropenyl acetate 
• 287-92-3 Cyclopentane 
• 75-05-8 acetonitrile 
• 96-41-3 Cyclopentanol 
• 1048692-95-0 2-azido-4,4,4,5-tetramethyl-1,3,2-dioxaborolane 
• 75-36-5 acetyl chloride 
• 142-29-0 cyclopentene 
• 137-43-9 Cyclopentyl bromide 
• 920-37-6 2-Chloroacrylonitrile 
• 60-35-5 acetamide 

Downstream Products

• 1177860-04-6 cyclopentyl ethylamine hydrochloride 

Relevant articles and documents

Decarboxylative Ritter-Type Amination by Cooperative Iodine (I/III)─Boron Lewis Acid Catalysis

Recent years have witnessed important progress in synthetic strategies exploiting the reactivity of carbocations via photochemical or electrochemical methods. Yet, most of the developed methods are limited in their scope to certain stabilized positions in molecules. Herein, we report a metal-free system based on the iodine (I/III) catalytic manifold, which gives access to carbenium ion intermediates also on electronically disfavored benzylic positions. The unusually high reactivity of the system stems from a complexation of iodine (III) intermediates with BF3. The synthetic utility of our decarboxylative Ritter-type amination protocol has been demonstrated by the functionalization of benzylic as well as aliphatic carboxylic acids, including late-stage modification of different pharmaceutical molecules. Notably, the amination of ketoprofen was performed on a gram scale. Detailed mechanistic investigations by kinetic analysis and control experiments suggest two mechanistic pathways.

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Alcohols as electrophiles: Iron-catalyzed Ritter reaction and alcohol addition to alkynes

A simple, iron-based catalytic system allows for a straightforward method for the synthesis of primary, secondary, and tertiary amides. The system also allows the addition of benzyl alcohols across phenylacetylene to produce substituted phenyl ketones. This transformation improves and expands the substrate scope beyond that previously reported and proceeds under mild reaction conditions, tolerating air and moisture.