25307-76-0

Basic information

• Product Name: Propanoic acid, 3-hydroxy-2,2-diMethyl-, 1,1-diMethylethyl ester
• Synonyms: Propanoic acid, 3-hydroxy-2,2-diMethyl-, 1,1-diMethylethyl ester;tert-Butyl 3-hydroxy-2,2-dimethylpropanoate
• CAS NO: 25307-76-0
• Molecular Formula: C₉H₁₈O₃
• Molecular Weight: 174.23742
• Mol File: 25307-76-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 241.1±13.0 °C(Predicted)
• Appearance: /
• Density: 0.977±0.06 g/cm3(Predicted)
• PKA: 14.17±0.10(Predicted)
• CAS DataBase Reference: Propanoic acid, 3-hydroxy-2,2-diMethyl-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-hydroxy-2,2-diMethyl-, 1,1-diMethylethyl ester(25307-76-0)
• EPA Substance Registry System: Propanoic acid, 3-hydroxy-2,2-diMethyl-, 1,1-diMethylethyl ester(25307-76-0)

Safety Data

• Hazardous Substances Data: 25307-76-0(Hazardous Substances Data)

Upstream product

• 85293-46-5 1-tert-butyl 3-methyl 2,2-dimethylmalonate 
• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 83766-88-5 2-tert-butoxypyridine 
• 50-00-0 formaldehyd 
• 23877-12-5 tert-butyl bromoisobutyrate 

Downstream Products

• 25307-79-3 tert-butyl 2,2-dimethyl-3-(tosyloxy)propanoate 
• 1443300-33-1 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(25,25-dimethyl-2,5,8,11,14,17,20,23-octaoxahexacosan-26-oate) 
• 1443300-55-7 tert-butyl 3-(2-(2-(benzyloxy)ethoxy)ethoxy)-2,2-dimethylpropanoate 

Relevant articles and documents

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.

HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions

A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride·diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of tert-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.