83766-88-5

Usage

Uses

Used in Organic Synthesis:
2-(tert-butoxy)pyridine is used as a reagent in various chemical reactions, such as oxidation and substitution reactions, due to its unique structure and reactivity.
Used in Coordination Chemistry:
2-(tert-butoxy)pyridine is used as a ligand in coordination chemistry, where it can form complexes with metal ions, contributing to the development of new coordination compounds with potential applications in catalysis, sensing, and other areas.
Used in Pharmaceutical Synthesis:
2-(tert-butoxy)pyridine serves as a precursor in the synthesis of pharmaceutical compounds, providing a starting material for the development of new drugs with potential therapeutic benefits.
Used in Materials Science:
2-(tert-butoxy)pyridine is utilized in the development of new organic semiconductors and optoelectronic devices, owing to its electronic properties and potential for molecular engineering in these fields.

Upstream product

• 372-48-5 2-fluoropyridine 
• 865-47-4 potassium tert-butylate 
• 109-09-1 2-chloropyridine 
• 110-86-1 pyridine 

Downstream Products

• 142-08-5 2-Pyridone 
• 115-11-7 isobutene 
• 774-65-2 benzoic acid tert-butyl ester 
• 13756-42-8 tert-butyl 4-methylbenzoate 
• 16537-18-1 tert-butyl 2-methylbenzoate 
• 833-79-4 t-butyl 4-methoxybenzoate 
• 58656-97-6 tert-butyl meta-methoxybenzoate 
• 712-95-8 tert-butyl 4-chlorobenzoate 
• 16537-17-0 3-chlorobenzoic acid tert-butyl ester 
• 69038-74-0 tert-butyl 3-bromobenzoate 
• 19756-72-0 tert-butyl 4-nitrobenzoate 
• 105580-41-4 4-acetylbenzoic acid tert-butyl ester 
• 16537-09-0 t-butyl phenylacetate 
• 16537-10-3 tert-butyl 3-phenylpropanoate 

Relevant academic research and scientific papers

Heterocyclic compound as well as preparation method and application thereof

The invention discloses a heterocyclic compound and a preparation method and application thereof. The invention provides a heterocyclic compound as shown in a formula I or pharmaceutically acceptable salt thereof. The compound has the function of inhibiting the activity of PU.1, and can inhibit the transcriptional activity based on liver cell PU.1 dependence and inhibit fibrosis development.

A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions

A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride·diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of tert-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.

Acid- and isobutylene-free synthesis of t-butyl ethers by in situ formation of 2-t-butoxy-1-methylpyridinium triflate

The title reagent is formed in situ by alkylation of 2-t-butoxypyrine. The subsequent addition of an alcohol substrate leads to the formation of t-butyl ethers without the need for isobutylene gas or acid activators.

Reactions of Caesium Fluoroxysulphate with Pyridine

Pyridine readily reacts with CsSO4F in various solvents at room temperature producing a mixture of up to three products (2-fluoropyridine, 2-pyridyl fluorosulfonate and 2-chloro or 2-alkoxypyridine), their distribution strongly depending on the solvent used.Reaction of 3-chloropyridine with CsSO4F in methanol leads regioselectively to 2-methoxy-3-chloropyridine, while 3-methylpyridine was converted into 2-methoxy-3-methyl and 2-methoxy-5-methylpyridine in a 2:1 relative ratio.

The Mechanisms of Thermal Eliminations. Part 11. Rate Data for Pyrolysis of 2-Alkoxypyridines to 2-Pyridone, and of 2-Ethoxypicolines to 2-Picolones: Nature and Polarity of the Transition State

The rates of thermal elimination of 2-ethoxy-, 2-isopropoxy-, 2-t-butoxy-pyridine to 2-pyridone and the corresponding alkene, and of the 2-ethoxy derivatives of 3-, 4-, 5-, and 6-methylpyridines to ethylene and the corresponding 2-picolines have been measured over at least 50 deg for each compound, between 585.1 and 721.1 K.The respective log (A/s-1) and Ea/kJ mol-1 values for the former three compounds are 12.20, 196.5; 12.68, 187.6; and 12.33, 161.0, and these are similar to those for the corresponding acetates.The relative rates of the first-order unimolecular decomposition at 600 K are: Et(1.0), Pri(18.0), But(1645) compared with 1.0:28.8:3316 for the acetates.The polarity of the transition state is thus less than for ester elimination.The difference in the rate ratios k(Pri)/k(Et) for alkoxypyridine and acetate pyrolyses is greater than the difference in the k(But)/k(Pri) ratios and is interpreted in terms of the difference in polarity of the transition states for primary, secondary, and tertiary elimination.Methyl substituents in the 3-, 4-, 5-, and 6-positions of the pyridine ring change the rate at 600 K by factors of 1.57, 1.02, 0.74, and 1.08, respectively.These show the decomposition does not take place via N-alkylpyridone tautomers, and that the reaction is, like ester pyrolysis, sterically accelerated.