34674-93-6

Upstream product

• 60-29-7 diethyl ether 
• 61604-72-6 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-oxopentanoate 
• 583-06-2 3-benzoylacrylic acid 
• 13389-88-3 5-oxo-2-phenyl-tetrahydro-furan-3-carboxylic acid 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 2051-95-8 succinylbenzene 
• 7647-01-0 hydrogenchloride 
• 24241-74-5 (+/-)-4-hydroxy-4-phenylbutanenitrile 
• 2243-53-0 styrylacetic acid 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 176850-44-5 4-Oxo-4-phenyl-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester 
• 176850-42-3 4-Oxo-4-phenyl-butyric acid (2S,3R,3aS,6R,6aR)-6-hydroxy-2-methoxy-hexahydro-furo[3,2-b]furan-3-yl ester 
• 53917-82-1 β-benzoylpropionyl chloride 
• 176850-50-3 4-Hydroxy-4-phenyl-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester 

Downstream Products

• 1821-12-1 4-Phenylbutyric acid 
• 71948-82-8 4-phenyl-4-acetoxybutanoic acid 
• 111138-02-4 (-)-(S)-5-phenyl-4,5-dihydrofuran-2(3H)-one 
• 111138-03-5 (R)-4-phenylbutyrolactone 
• 2051-95-8 succinylbenzene 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 6638-33-1 6-phenyltetrahydro-1,3-oxazin-2-one 
• 4850-50-4 1-phenyl-butane-1,4-diol 
• 92010-34-9 (S)-1-[4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyryl]-pyrrolidine-2-carboxylic acid 2-benzyloxycarbonyl-phenyl ester 
• 92010-32-7 1-<4-<(tert-butyldimethylsilyl)oxy>-4-phenylbutyryl>-L-proline benzyl ester 
• 92010-35-0 (S)-1-(4-Hydroxy-4-phenyl-butyryl)-pyrrolidine-2-carboxylic acid 2-carboxy-phenyl ester 
• 92010-33-8 1-<4-<(tert-butyldimethylsilyl)oxy>-4-phenylbutyryl>-L-proline 
• 92010-31-6 4-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanoic acid 

Relevant academic research and scientific papers

Nickel-Catalyzed Asymmetric Hydrogenation of γ-Keto Acids, Esters, and Amides to Chiral γ-Lactones and γ-Hydroxy Acid Derivatives

A highly efficient asymmetric hydrogenation of a series of γ-keto acid derivatives, including γ-keto acids, esters, and amides, using a Ni-(R,R)-QuinoxP? complex as the catalyst has been developed to afford chiral γ-hydroxy acid derivatives with excellent enantioselectivities, up to 99.9% ee. This method provides not only an economical one-pot approach for the synthesis of chiral γ-lactones but also access to (S)-norfluoxetine, an inhibitor of neural serotonin reuptake and an essential intermediate for pharmaceutical synthesis.

Sodium Aminodiboranate, a New Reagent for Chemoselective Reduction of Aldehydes and Ketones to Alcohols

Sodium aminodiboranate (NaNH 2(BH 3) 2, NaADBH) is a new member of the old borane family, which exhibits superior performance in chemoselective reduction. Experimental results show that NaADBH can rapidly reduce aldehydes and ketones to the corresponding alcohols in high efficiency and selectivity under mild conditions. There are little steric and electronic effects on this reduction.

Organic metal compound and process for preparing optically-active alcohols using the same

The present invention provides an asymmetric reduction catalyst effective in preparing optically-active alcohol compounds having various functional groups, and a process for preparing optically-active alcohol compounds using said asymmetric reduction catalyst. The organic metal compound of the present invention is represented by the following general formula (1): wherein R1 and R2 may be mutually identical or different, and are an alkyl group, a phenyl group, a naphthyl group, a cycloalkyl group, or an alicyclic ring formed by binding R1 and R2, which may have a substituent; R3 is a hydrogen atom or an alkyl group; Cp is a cyclopentadienyl group, which may have a substituent, bound to M1 via a π bond; X1 is a halogen atom or a hydrido group; M1 is rhodium or iridium; and * denotes asymmetric carbon.

Exploring the synthetic applicability of a cyanobacterium nitrilase as catalyst for nitrile hydrolysis

The substrate specificity and synthetic applicability of the nitrilase from cyanobacterium Synechocystis sp. strain PCC 6803 have been examined. This nitrilase catalyzed the hydrolysis of both aromatic and aliphatic nitriles to the corresponding acids in high yields. Furthermore, the stereoselective hydrolysis of phenyl-substituted β-hydroxy nitriles to (S)-enriched β-hydroxy carboxylic acids and selective hydrolysis of α,ω- dinitriles with five or less methylene groups to ω-cyano carboxylic acids have been achieved. This suggested that nitrilase from Synechocystis sp. PCC 6803 could be a useful enzyme catalyst for the "green" nitrile hydrolysis. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation

To explore the synthetic potential of nitrilase ZmNIT2 from maize, the substrate specificity of this nitrilase was studied with a diverse collection of nitriles. The nitrilase ZmNIT2 showed high activity for all the tested nitriles except benzonitrile, producing both acids and amides. For the hydrolysis of aliphatic, aromatic nitriles, phenylacetonitrile derivatives and dinitriles, carboxylic acids were the major products. Unexpectedly, amides were found to be the major products in nitrilase ZmNIT2-catalyzed hydrolysis of β-hydroxy nitriles. The hydrogen bonding between the hydroxyl group and nitrogen in the enzyme-substrate complex intermediates that disfavors the loss of ammonia and formation of acyl-enzyme intermediate, which was further hydrolyzed to acid, was proposed to be responsible for the unprecedented β-hydroxy functionality assisted high yield of amide formation.

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1

Asymmetric induction using novel chiral auxiliaries derived from D-glucose

Asymmetric synthesis of lactones 15a-16b, using the novel auxiliaries 1 and 2 readily available from D-glucose, is described.

Design, synthesis, and testing of potential antisickling agents. 5. Disubstituted benzoic acids designed for the donor site and proline salicylates designed for the acceptor site

This paper reports the discovery of a new class of potent antigelling agents. The new compounds, disubstituted benzoic acid derivatives, were designed by using molecular modeling experiments. These molecules contain functional groups positioned to interac