253590-67-9

Basic information

• Product Name: 1,3-di-[N-benzyl-N-[[(S)-tetrahydrofur-3-yloxy]carbonyl]amino]-2-hydroxypropane
• Synonyms: 1,3-di-[N-benzyl-N-[[(S)-tetrahydrofur-3-yloxy]carbonyl]amino]-2-hydroxypropane
• CAS NO: 253590-67-9
• Molecular Weight: 498.576
• Mol File: 253590-67-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-di-[N-benzyl-N-[[(S)-tetrahydrofur-3-yloxy]carbonyl]amino]-2-hydroxypropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-di-[N-benzyl-N-[[(S)-tetrahydrofur-3-yloxy]carbonyl]amino]-2-hydroxypropane(253590-67-9)
• EPA Substance Registry System: 1,3-di-[N-benzyl-N-[[(S)-tetrahydrofur-3-yloxy]carbonyl]amino]-2-hydroxypropane(253590-67-9)

Safety Data

• Hazardous Substances Data: 253590-67-9(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 65838-17-7 1,3-di-(N-benzylamino)-2-hydroxypropane 
• 138499-08-8 1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione 

Downstream Products

• 253590-99-7 Benzyl-(3-{benzyl-[(S)-(tetrahydro-furan-3-yl)oxycarbonyl]-amino}-2-oxo-3-phenylsulfanyl-propyl)-carbamic acid (S)-(tetrahydro-furan-3-yl) ester 
• 253590-80-6 Benzyl-(3-{benzyl-[(S)-(tetrahydro-furan-3-yl)oxycarbonyl]-amino}-2-oxo-propyl)-carbamic acid (S)-(tetrahydro-furan-3-yl) ester 

Relevant articles and documents

Synthesis and anti-HIV activity of α-thiophenoxy-hydroxyethylamide derivatives

A series of new anti-HIV derivatives containing a novel α- thiophenoxyhydroxyethylamide core have been synthesized, using S- phenylbenzenethiosulfonate as the thiosulfenylating reagent. Some of the new synthesized compounds (1a, 1c, 1g, 1i, 1j and 1l) inhibited HIV replication in cell culture assays (syncytia formation) with effective concentrations (EC50) ranging from 0. 1-1 μM. Incorporation of thiophenoxy substitution within various pseudomimetic peptide backbones provided a series of highly potent HIV inhibitors.