253674-46-3

Upstream product

• 108-24-7 acetic anhydride 
• 100-39-0 benzyl bromide 
• 253674-43-0 N-[(1R,2S,3R,4S,6S)-2-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-methyl-3-vinyl-7-oxa-bicyclo[4.1.0]hept-3-yl]-2,2,2-trichloro-acetamide 
• 253674-44-1 N-[(1R,2S,3R,4S,6S)-2-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-formyl-6-methyl-7-oxa-bicyclo[4.1.0]hept-3-yl]-2,2,2-trichloro-acetamide 
• 253674-40-7 2,2,2-Trichloro-N-[(1R,2S,4S,5S)-4,5-dibromo-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-1-vinyl-cyclohexyl]-acetamide 
• 162089-64-7 (1S,6S,1'S)-trichloro-N-[1-vinyl-4-methyl-6-(3',3'-dimethyl-2',4'-dioxolanyl)-cyclohex-3-enyl]acetamide 
• 352670-24-7 2,2,2-Trichloro-N-[(1R,2S,3R,4S,6S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-6-methyl-3-vinyl-7-oxa-bicyclo[4.1.0]hept-3-yl]-acetamide 
• 253674-42-9 2,2,2-Trichloro-N-[(1R,2S,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-4-methyl-1-vinyl-cyclohex-3-enyl]-acetamide 
• 253674-39-4 2,2,2-Trichloro-N-[(1R,2R,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-4-methyl-1-vinyl-cyclohex-3-enyl]-acetamide 
• 271256-59-8 2,2,2-Trichloro-N-[(1R,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-2-oxo-1-vinyl-cyclohex-3-enyl]-acetamide 
• 253674-41-8 (3aR,4S,7aS)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-methyl-2-trichloromethyl-3a-vinyl-3a,4,5,7a-tetrahydro-benzooxazole 

Downstream Products

• 352670-32-7 (1S,4S,5R,6S,8S,9S)-9-(benzyloxy)-6-(dimethoxymethyl)-8-hydroxy-8-methyl-3-oxo-5-(2,2,2-trichloroacetamido)-2-oxabicyclo[3.3.1]nonan-4-yl acetate 
• 253674-50-9 Acetic acid (1S,4S,6R,7S,8R,9S,10S)-9-benzyloxy-8-(3-benzyl-ureido)-6-methoxy-10-methyl-3-oxo-2,5-dioxa-tricyclo[5.2.2.0^4,8]undec-10-yl ester 
• 253674-49-6 Acetic acid (1S,4S,5R,6S,8S,9S)-8-acetoxy-9-benzyloxy-6-dimethoxymethyl-8-methyl-3-oxo-5-(2,2,2-trichloro-acetylamino)-2-oxa-bicyclo[3.3.1]non-4-yl ester 
• 352670-33-8 Acetic acid (1S,4S,5R,6S,8S,9S)-8-acetoxy-9-benzyloxy-5-(3-benzyl-ureido)-6-dimethoxymethyl-8-methyl-3-oxo-2-oxa-bicyclo[3.3.1]non-4-yl ester 
• 253674-47-4 Acetic acid (1S,4S,5R,6S,8S,9S)-9-benzyloxy-5-(3-benzyl-ureido)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-8-hydroxy-8-methyl-3-oxo-2-oxa-bicyclo[3.3.1]non-4-yl ester 
• 253674-52-1 Acetic acid (1S,4S,6R,7S,8R,9S,10S)-8-(N'-acetyl-N',N''-dibenzyl-guanidino)-9-benzyloxy-6-methoxy-10-methyl-3-oxo-2,5-dioxa-tricyclo[5.2.2.0^4,8]undec-10-yl ester 
• 352670-30-5 C₂₅H₂₆N₂O₆ 
• 352670-29-2 1-Benzyl-3-[(1S,4S,5S,6S,8S,9S)-9-benzyloxy-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,8-dihydroxy-8-methyl-3-oxo-2-oxa-bicyclo[3.3.1]non-5-yl]-urea 
• 253674-37-2 Acetic acid (1S,4S,5R,6S,8S,9S)-9-benzyloxy-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-8-hydroxy-8-methyl-3-oxo-5-(2,2,2-trichloro-acetylamino)-2-oxa-bicyclo[3.3.1]non-4-yl ester 

Relevant academic research and scientific papers

Stereocontrolled synthesis of (-)-5,11-dideoxytetrodotoxin

Asymmetric synthesis of (-)-5,11-dideoxytetrodotoxin, an analog of puffer fish toxin, was accomplished from a common key intermediate through a novel hydroxylation at the C-8 position with neighboring group participation of trichloroacetamide, a highly st

Stereocontrolled synthesis of (-)-5,11-dideoxytetrodotoxin

New derivatives of an intriguing marine natural product are now accessible. The first asymmetric synthesis of the simple tetrodotoxin analogue, 5,11-dideoxytetrodotoxin (3), was achieved. Hydroxylation at position C8 of the key intermediate 1 relied on th