25369-03-3 Usage
General Description
2,4-DIPHENYL-3-OXOBUTYRONITRILE is a chemical compound with the molecular formula C18H13NO. It is a yellow crystalline solid that is used in chemical research and synthesis. 2,4-DIPHENYL-3-OXOBUTYRONITRILE is classified as a nitrile, which means it contains a carbon triple-bonded to a nitrogen atom. It is also a ketone, containing a carbonyl group (C=O) within its structure. 2,4-DIPHENYL-3-OXOBUTYRONITRILE is commonly used as a building block in the synthesis of various organic compounds and is known for its reactivity in organic reactions due to the presence of the nitrile and ketone functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 25369-03-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,3,6 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 25369-03:
(7*2)+(6*5)+(5*3)+(4*6)+(3*9)+(2*0)+(1*3)=113
113 % 10 = 3
So 25369-03-3 is a valid CAS Registry Number.
25369-03-3Relevant articles and documents
Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors
Petek, Nejc,?tefane, Bogdan,Novinec, Marko,Svete, Jurij
, p. 226 - 238 (2018/12/04)
A series of novel 7-aminoalkyl substituted pyrazolo[1,5-a]pyrimidine derivatives were synthesized and tested for inhibition of cathepsin K. The synthetic methodology comprises cyclization of 5-aminopyrazoles with N-Boc-α-amino acid-derived ynones followed by transformation of the ester and the Boc-amino functions. It allows for easy diversification of the pyrazolo[1,5-a]pyrimidine scaffold at various positions. Molecular docking studies with pyrazolo[1,5-a]pyrimidine derivatives were also performed to elucidate the binding mode in the active site of cathepsin K. The synthesized compounds exhibited moderate inhibition activity (Ki ≥ 77 μM).
