253769-57-2Relevant academic research and scientific papers
1,2-Dihydro-4-quinazolinamines: Potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo
Tinker, Alan C.,Beaton, Haydn G.,Boughton-Smith, Nigel,Cook, Tony R.,Cooper, Sally L.,Fraser-Rae, Lynne,Hallam, Kay,Hamley, Peter,McInally, Tom,Nicholls, David J.,Pimm, Austen D.,Wallace, Alan V.
, p. 913 - 916 (2007/10/03)
The discovery of a novel class of nitric oxide synthase (NOS) inhibitors, 2-substituted 1,2-dihydro-4-quinazolinamines, and the related 4′-aminospiro[piperidine-4,2′(1′H)-quinazolin]- 4′-amines is described. Members of both series exhibit nanomolar potenc
Pharmaceutical combination comprising a COX-2 inhibitor and a iNOS inhibitor
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, (2008/06/13)
The invention relates to the co-administration of an inhibitor of induced nitric oxide synthase and an inhibitor of cyclooxygenase-2 for the treatment of inflammation and inflammatory disorders.
