4392-06-7Relevant academic research and scientific papers
NOVEL ANTIPARASITIC COMPOUNDS AND METHODS
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Page/Page column 95-96, (2021/04/23)
Novel compounds for treating or inhibiting leishmaniasis and other parasitic protozoan diseases are disclosed herein. The compounds bind to Leishmania tubulin, induce parasite microtubule polymerization, stall Leishmania cell division, and have broad antiparasitic activity.
A Highly Efficient Copper-Catalyzed Three-Component Synthesis of 4-Aminoquinazolines
Yang, Lei,Luo, Honghua,Sun, Yan,Shi, Zhenyu,Ni, Kaidong,Li, Fei,Chen, Dongyin
, p. 2535 - 2535 (2017/05/22)
A highly efficient copper-catalyzed one-pot protocol is developed for the synthesis of 4-aminoquinazolines from easily available 2-iodo- or 2-bromobenzimidamides, aldehydes, and sodium azide. This one-pot approach proceeds via consecutive copper-catalyzed SNAr substitution, reduction, cyclization, oxidation and tautomerization. The corresponding target products (26 examples) are obtained in 50-90% yield.
1,2-Dihydro-4-quinazolinamines: Potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo
Tinker, Alan C.,Beaton, Haydn G.,Boughton-Smith, Nigel,Cook, Tony R.,Cooper, Sally L.,Fraser-Rae, Lynne,Hallam, Kay,Hamley, Peter,McInally, Tom,Nicholls, David J.,Pimm, Austen D.,Wallace, Alan V.
, p. 913 - 916 (2007/10/03)
The discovery of a novel class of nitric oxide synthase (NOS) inhibitors, 2-substituted 1,2-dihydro-4-quinazolinamines, and the related 4′-aminospiro[piperidine-4,2′(1′H)-quinazolin]- 4′-amines is described. Members of both series exhibit nanomolar potenc
