254112-83-9Relevant academic research and scientific papers
On the question of the diastereoselective alkylation of 4-unsubstituted 3-amino β-lactams. A concise synthesis of α-branched α-amino β-lactams and their coupling with α-amino acid esters
Palomo, Claudio,Aizpurua, Jesus M.,Galarza, Regina,Benito, Ana,Khamrai, Uttam K.,Eikeseth, Unni,Linden, Anthony
, p. 5563 - 5570 (2007/10/03)
The reaction of [(4S)-2-oxo-4-phenyloxazolidin-3-yl]acetic acid chloride with N-methylidene-bis-[(trimethylsilyl)methyl]amine and triethylamine in refluxing chloroform leads to a 4-unsubstituted β-lactam able to undergo highly asymmetric alkylations at th
α-alkyl-α-amino-β-lactam peptides: Design, synthesis, and conformational features
Palomo, Claudio,Aizpurua, Jesus M.,Benito, Ana,Galarza, Regina,Khamrai, Uttam K.,Vazquez, Jordi,De Pascual-Teresa, Beatriz,Nieto, Pedro M.,Linden, Anthony
, p. 3056 - 3058 (2007/10/03)
Remarkable asymmetric induction is achieved in the alkylation of the lithium enolate of the β-lactam 1. This allows the first time access to a new family of peptidomimetics 2 with predictable conformational constraints.
