25452-29-3Relevant academic research and scientific papers
HIV Integrase Inhibitors
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Page/Page column 50, (2009/10/17)
The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
A new approach to the synthesis of N-arylakyl aminoalcohols
Leskovsek,Urleb
, p. 1415 - 1424 (2007/10/02)
N-arylmethyl substituted aminoalcohols were prepared by enantioselective reductive amination of different aromatic and heteroaromatic aldehydes using aminoalcohols and NaBH3CN as a catalyst. The reaction of optically active aminoalcohols afforded optically pure products.
Reductive Cleavage of Aryl Oxazolines to Benzaldehydes and Substituted Toluenes
Meyers, A. I.,Himmelsbach, Richard J.,Reuman, Michael
, p. 4053 - 4058 (2007/10/02)
Aryl oxazolines have been converted to their corresponding benzaldehydes and toluenes by several routes by passing through the intermediate amino alcohols.The transformations proceeded under mild conditions and were shown to be generally applicable to a variety of substitutions on the aromatic nucleus.
