25477-76-3Relevant academic research and scientific papers
Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors
Prins, Louis H. A.,Petzer, Jacobus P.,Malan, Sarei F.
experimental part, p. 7523 - 7530 (2011/02/23)
Monoamine oxidase B (MAO-B) and nitric oxide synthase (NOS) have both been implicated in the pathology of neurodegenerative diseases. In an attempt to design dual-target-directed drugs that inhibit both these enzymes, a series of pteridine-2,4-dione analo
Synthesis, DNA binding and antiviral activity of new uracil, xanthine, and pteridine derivatives
El-Sabbagh, Osama I.,El-Sadek, Mohamed E.,El-Kalyoubi, Samar,Ismail, Ibrahim
, p. 26 - 31 (2008/01/27)
Some new 6-amino-1,3-dimethyl-5-(substituted methylidene)aminouracils were synthesized. Most of them were cyclized with triethyl orthoformate as a one-carbon source to afford 1,3-dimethyl-6-substituted pteridine derivatives. Certain uracils gave xanthine
Solvent-free regioselective synthesis of 6- and 7-substituted pteridines under microwave irradiation
Singh,Geetanjali
, p. 136 - 138 (2007/10/03)
Reactions of 5,6-diaminouracils with α-keto aldehydes over acidic and neutral aluminum oxide under microwave irradiation gave the corresponding 6- and 7-substituted 1,2,3,4-tetrahydropteridine-2,4-diones in 63-79% yield with high regioselectivity. Pleiade
A novel method for introduction of carbon substituents into pteridine
Murata, Shizuaki,Kujime, Masato,Sugimoto, Takashi,Murakami, Katsuhiko,Seo, Chihiro
, p. 117 - 124 (2007/10/03)
A reaction of 1,3-dimethyl-6-trifluoromethanesulfonyloxylumazine with an anion of a 1,3-dicarbonyl compound such as diethyl malonate and 1,3- cyclohexanedione gives the corresponding 6-substituted lumazine.
Facile synthesis of 6-aryl-1,3-dimethyl-5H-pyrimido-[4,5-b][1,4]diazepine-2,4(1H,3H)-diones
Taghavi-Moghadam, Shahriyar,Stumpf, Ruediger,Fischer, Helmut,Pfleiderer, Wolfgang
, p. 313 - 320 (2007/10/03)
A facile procedure for the preparation of 6-aryl-1,3-dimethyl-5H-pyrimido[4,5-b][1,4]diazepine-2,4(1H,3H)-diones 8, 9 from 6-amino-5-arylideneamino-1,3-dimethyluracils 1, 2 and triethyl orthoacetate (3) in a two-step reaction via 6-aryl-8-ethoxy-6,7-dihydro-1,3-dimethyl-5H-pyrimido[4,5-b][1,4]diazepine-2,4(1H ,3H)-diones 6, 7 is described. Condensation of 1 with diethoxymethyl acetate (10) resulted in the formation of (1,3-dimethyl-2,6-(1H,3H)-dioxopurin-7-yl)(phenyl)methyl acetate (11) and a small amount of 1,3-dimethyl-6-phenyl-pyrazino[2,3-d]pyrimidine-2,4(1H,3H)-dione (12). The structures of 6 and 11 were unambiguously confirmed by single-crystal X-ray diffraction analysis.
Regiospecific synthesis of 6-alkylated lumazine derivatives using silylenol ethers
Igarashi, Mamoru,Tada, Masaru
, p. 465 - 466 (2007/10/03)
The reaction of oxadiazinone with silylenol ethers gave regiospecifically 6-substituted lumazines by an hetero Diels-Alder addition followed by decarboxylation and silanol elimination.
Regioselective Synthesis of 6-Alkylated Lumazine Derivatives
Igarashi, Mamoru,Tada, Masaru
, p. 807 - 810 (2007/10/02)
The regiospecific synthesis of alkylated lumazines is achieved by hetero Diels-Alder addition between an oxadiazinone 2 and enamine.The reactions proceed stepwise by cycloaddition, decarboxylation and deamination to produce the 6-alkylated lumazines.
A NEW CONTRACTION OF PTERIDINE 5-OXIDES TO PURINES AND A 7-DEAZAPURINE BY THE 1,3-DIPOLAR CYCLOADDITION REACTION
Ichiba, Misuzu,Kanazawa, Hashime,Tamura, Zenzo,Senga, Keitaro
, p. 2317 - 2319 (2007/10/02)
The 1,3-dipolar cycloaddition reaction of pteridine 5-oxides with dimethyl acetylenedicarboxylate resulted in a new ring contraction of the pyrazine moiety to give purines and a 7-deazapurine.
