60228-89-9

Upstream product

• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 100-52-7 benzaldehyde 
• 57196-71-1 6-amino-1,3-dimethyl-5-(1-p-tolyl-ethylideneamino)-1H-pyrimidine-2,4-dione 

Downstream Products

• 961-45-5 8-phenyltheophylline 
• 25477-76-3 1,3-Dimethyl-6-phenylpyrazino<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 70404-36-3 N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N,N'-dibenzylthiourea 
• 75724-47-9 N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-benzylacetamide 
• 75735-08-9 N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-benzyl-formamide 
• 58481-36-0 6-amino-5-(benzylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 67-71-0 dimethylsulfone 
• 961-45-5 1,3-dimethyl-8-phenylxanthine 

Relevant academic research and scientific papers

Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors

Monoamine oxidase B (MAO-B) and nitric oxide synthase (NOS) have both been implicated in the pathology of neurodegenerative diseases. In an attempt to design dual-target-directed drugs that inhibit both these enzymes, a series of pteridine-2,4-dione analo

REACTIONS OF 5,6-DIAMINO-1,3-DIMETHYLURACIL WITH CARBONYL COMPOUNDS

Teh first step in the acid-catalyzed reaction of 5,6-diamino-1,3-dimethyluracil with carbonyl compounds is the formation of an azomethine at the 5-amino group.Chalcone derivatives undergo a further substitution; the 6-amino group is replaced by a hydroxyl group with subsequent ring closure and the formation of 2,3-dihydro-1,5-oxazepine ring.Azomethines based on arylidenacetones form 2,3-dihydropyrimidino-1,5-diazepine derivatives.

REACTION OF 5,6-DIAMINO-1,3-DIMETHYLURACIL WITH CHALCONES

2,4-Diaryl-7,9-dimethyl-6,8-dioxo-2,3-dihydropyrimidino-1,5-oxazepines are formed instead of the expected dihydrodiazepine derivatives in the reaction of chalcones with 5,6-diamino-1,3-dimethyluracil (I) in the presence of acetic acid.The reaction