254891-74-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 254891-73-1 (3S,6R)-3-acetoxy-6,7-dihydroxyhept-1-yne 
• 36326-38-2 ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 
• 133008-09-0 (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propanal 
• 254891-72-0 (3S,6R)-3-acetoxy-6,7-(isopropylidenedioxy)hept-1-yne 
• 253867-17-3 ethyl (2E,6R)-6,7-(isopropylidenedioxy)hept-2-enoate 
• 254891-69-5 (2S,3S,6R)-2,3-epoxy-6,7-(isopropylidenedioxy)heptan-1-ol 
• 254891-70-8 (2R,3S,6R)-1-chloro-2,3-epoxy-6,7-(isopropylidenedioxy)heptane 
• 254891-71-9 (3S,6R)-3-hydroxy-6,7-(isopropylidenedioxy)hept-1-yne 
• 253867-18-4 (2E,6R)-6,7-(isopropylidenedioxy)hept-2-en-1-ol 
• 173152-84-6 ethyl (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionate 
• 133008-08-9 (4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol 

Downstream Products

• 254891-68-4 (2S,5S)-5-ethynyl-2-[(p-toluenesulfonyloxy)methyl]tetrahydrofuran 
• 253866-88-5 (2S,5S)-2-ethynyl-5-[(4-fluorophenoxy)methyl]tetrahydrofuran 
• 254891-67-3 (2S,5S)-5-ethynyl-2-(hydroxymethyl)tetrahydrofuran 

Relevant academic research and scientific papers

Stereoselective syntheses of pharmaceutically relevant chiral tetrahydrofurans from (S)- and (R)-glyceraldehyde derivatives

A practically simple and flexible method of making chiral tetrahydrofurans of therapeutic relevance is reported from glyceraldehyde derivatives as chiral synthons. One of the stereocentres is derived from glyceraldehyde derivatives, while the other one is introduced by Sharpless asymmetric epoxidation using either (+)- or (-)-DIPT.

Methods for synthesis of substituted tetrahydrofuran compound

The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.