16299-27-7Relevant academic research and scientific papers
Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII
Angeli, Andrea,Capasso, Clemente,De Luca, Laura,Del Prete, Sonia,Gitto, Rosaria,Mancuso, Francesca,Supuran, Claudiu T.
, p. 1442 - 1449 (2020)
Coumarins are widely diffused secondary metabolites possessing a plethora of biological activities. It has been established that coumarins represent a peculiar class of human carbonic anhydrase (hCA) inhibitors having a distinct mechanism of action involv
Synthesis and in vitro evaluation of leishmanicidal activity of 7-hydroxy-4-phenylcoumarin derivatives
Rosa, Isael A.,de Almeida, Letícia,Alves, Karina F.,Marques, Marcos J.,Fregnan, Ant?nio M.,Silva, Claudinei A.,Giacoppo, Juliana O. S.,Ramalho, Teodorico C.,Carvalho, Diogo T.,dos Santos, Marcelo H.
, p. 131 - 139 (2017/01/12)
Eight coumarin derivatives (2–8) were synthesized from 7-hydroxy-4-phenylcoumarin 1 and were evaluated for their in vitro leishmanicidal activity against promastigote and amastigote forms of Leishmania amazonensis, as well their toxicity in murine macroph
Synthesis and biological activity of meso-tetrakis (2,10-dioxo-2H, 10H-pyrano [2,3-f] chromene-9-yl) porphyrins
Kumar, V. Naveen,Thirupathi Reddy,Narasimhareddy,Rajitha,De Clercq
, p. 181 - 188 (2013/09/12)
Synthesis of meso-tetrakis (2, 10-dioxo-2H, 10H-pyrano[2,3-f] chromene-9-yl) porphyrins are synthesized directly by reaction of pyrrole with substituted 4-methyl-2,10-dioxo-2H, 10H-pyrano[2,3-f]chromene-9-carbaldehydes in dichloromethane / acid media. The aldehyde's molar ratio was controlled to optimize the synthesis and purification of the desired porphyrins. This new series of porphyrins was characterized by TLC, Mass Spectrometry (FAB mass), 1H NMR, UV and IR ARKAT.
An efficient ZrCl4 catalyzed one-pot solvent free protocol for the synthesis of 4-substituted coumarins
Sharma,Janardhan Reddy,Sree Lakshmi,Radha Krishna
, p. 6119 - 6121 (2007/10/03)
A versatile and efficient route to 4-substituted coumarins via a Pechmann reaction using ZrCl4 as the catalyst (10 mol %) is described. This method provides several advantages over alternative procedures such as mild, solvent-free conditions at ambient temperature, and direct isolation of the products in high yields.
