108979-94-8

Upstream product

• 64-67-5 diethyl sulfate 
• 2555-30-8 7-hydroxy-4-phenylcoumarin 
• 131-57-7 Benzophenone-3 
• 105-53-3 diethyl malonate 
• 2555-31-9 7-methoxy-4-phenyl-2H-chromen-2-one 
• 31005-02-4 7-ethoxycoumarin 
• 98-80-6 phenylboronic acid 
• 587-85-9 diphenylmercury(II) 

Downstream Products

• 101894-35-3 6-acetoxy-7-ethoxy-4-phenyl-coumarin 
• 107683-56-7 7-ethoxy-6-methoxy-4-phenyl-coumarin 
• 101451-76-7 7-ethoxy-6-hydroxy-4-phenyl-coumarin 

Relevant academic research and scientific papers

A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction

A straightforward and atom-economical base-free palladium-catalyzed regioselective direct arylation of coumarins and chromenones is devised. This protocol is compatible with a wide variety of electron-donating and -withdrawing substituents and allows construction of various biologically important flavone and neoflavone backbones.

Microwave-promoted, one-pot, solvent-free synthesis of 4-arylcoumarins from 2-hydroxybenzophenones

4-Arylcoumarins are synthesized in very good yields through solvent-free microwave irradiation of 2-hydroxybenzophenones and alkyl malonate in the presence of DBU. The onepot synthesis is carried out with Knoevenagel condensation, intramolecular lactonization, and decarboxylation reactions. The method can be applied to a broad scope of neoflavonoids.

Selective phenylation of naphthoquinones and coumarins using diphenylmercury

Under the influence of UV light, 1,4-naphthoquinones 1-5 and coumarins 6-10 on reaction with diphenylmercury in acetonitrile under nitrogen atmosphere give corresponding 2-phenyl-1,4-naphthoquinones 11-15 and 4-phenylcoumarins 16-20.