255724-72-2

Basic information

• Product Name: 1H-INDOLE, 6-FLUORO-2-PHENYL-
• Synonyms: 1H-INDOLE, 6-FLUORO-2-PHENYL-;6-FLUORO-2-PHENYL-1H-INDOLE
• CAS NO: 255724-72-2
• Molecular Formula: C₁₄H₁₀FN
• Molecular Weight: 211.238
• Mol File: 255724-72-2.mol
• Article Data: 30

Chemical Properties

• Melting Point: 171-172℃
• Boiling Point: 395.755°C at 760 mmHg
• Flash Point: 193.146°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-INDOLE, 6-FLUORO-2-PHENYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE, 6-FLUORO-2-PHENYL-(255724-72-2)
• EPA Substance Registry System: 1H-INDOLE, 6-FLUORO-2-PHENYL-(255724-72-2)

Safety Data

• Hazardous Substances Data: 255724-72-2(Hazardous Substances Data)

Usage

General Description

1H-Indole, 6-fluoro-2-phenyl- is a chemical compound with the molecular formula C14H10FN. It is a derivative of indole, which is a heterocyclic compound commonly found in various natural products. This particular compound is characterized by the presence of a fluorine atom at the 6th position and a phenyl group at the 2nd position of the indole ring. It is used in the field of organic synthesis as a building block for the creation of various pharmaceuticals and agrochemicals. Additionally, the presence of the fluorine atom makes it a potential candidate for use in medicinal chemistry and drug development. Its unique structure and potential biological activities make it a subject of interest for further research and exploration.

InChI:InChI=1/C14H10FN/c15-12-7-6-11-8-13(16-14(11)9-12)10-4-2-1-3-5-10/h1-9,16H

Upstream product

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Relevant articles and documents

Iron-catalysed radical cyclization to synthesize germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones

A simple and efficient strategy for iron-catalysed cascade radical cyclization was developed, by which an array of germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones were obtained in one pot with germanium hydrides as radical precursors. A rapid intramolecular radical trapping mode enabled the selective arylgermylation of alkenes over the prevalent hydrogermylation reaction.

Well-defined (NHC)Pd(N–heterocyclic carboxylate)(OAc) complexes-catalyzed direct C2-arylation of free (NH)-indoles with arylsulfonyl hydrazides

A series of well-defined (NHC)Pd(N–heterocyclic carboxylate)(OAc) complexes (N–heterocyclic carboxylate = pyridine-2-carboxylate, quinoline-2-carboxylate and isoquinoline-1-carboxylate) were synthesized and fully characterized by NMR spectra, HR-MS and X-ray single crystal diffraction. The obtained complexes were then used for direct C2-arylation of free (NH)-indoles with arylsulfonyl hydrazides. With low catalyst loading, all complexes exhibited high catalytic activities for the arylation reactions.

Pd-Catalyzed Reductive Cyclization of Nitroarenes with CO2 as the CO Source

A reductive amination process that constructs indoles, carbazoles or benzimidazoles from nitroarenes – irrespective of their electronic or steric nature – was developed that uses CO2 as the source of CO. The process is robust, tolerating common gaseous components of flue gas (H2S, SO2, NO and H2O) without adversely affecting the reductive cyclization.