25574-93-0

Usage

Physical Appearance

White to light brown crystalline solid

Melting Point

165-169°C

Primary Uses

UV stabilizer
Production of polymers and resins
Crosslinking agent in synthetic rubber manufacture
Intermediate in pharmaceutical and agrochemical production

Safety Considerations

May cause irritation to eyes, skin, and respiratory system
Harmful if swallowed or inhaled

Upstream product

• 122-39-4 diphenylamine 
• 74-86-2 acetylene 
• 79-10-7 acrylic acid 
• 814-68-6 acryloyl chloride 
• 26064-89-1 3-chloro-N,N-diphenyl-propionamide 

Downstream Products

• 119163-28-9 Oxirane-2-carboxylic acid diphenylamide 
• 64754-65-0 (2E)-N,N,3-triphenylprop-2-enamide 
• 50395-70-5 N,N-diphenylcinnamamide 

Relevant academic research and scientific papers

Method for catalytically synthesizing acrylamide compound by MOFs-derived zirconium-based ternary oxide solid acid

The invention provides a catalytic synthesis of acrylamide compounds with zirconium-based ternary oxide solid acid as a catalyst, and the low-temperature activity is good. In the synthesis process, the acid is small, the reaction conditions are mild and controllable, the byproducts are few, the reaction yield is effectively improved, the purity is high, the quality is good, and the method is suitable for large-scale production.

Adhesive composition

PROBLEM TO BE SOLVED: To provide an adhesive composition having excellent adhesion to a cycloolefin resin or the like. SOLUTION: An adhesive composition of the present invention comprises a polymer having a repeating unit derived from a polymerizable comp

Electrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes

Radical fluoroalkylation of alkenes has been developed by electrochemical reduction of fluoroalkyl sulfones. A series of electron-deficient alkenes readily undergo hydrofluoroalkylation in good to excellent yields. This chemistry represents the first example of electrochemical generation of fluoroalkyl radicals from sulfones, which are used for practical radical fluoroalkylation of organic compounds.

Rh(i)-Catalyzed regioselective arylcarboxylation of acrylamides with arylboronic acids and CO2

The first Rh(i)-catalyzed regioselective arylcarboxylation of electron-deficient acrylamides with arylboronic acids under atmospheric pressure of CO2 has been developed. A range of acrylamides and arylboronic acids were compatible with this reaction under redox-neutral conditions, leading to a series of malonate derivatives that are versatile building blocks in organic syntheses.

COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A

Disclosed herein, inter alia, are compositions and methods useful for modulating PPP2R1 A and for the treatment of cancer.

COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4

Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).

Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity

Chemical genetics has arisen as a powerful approach for identifying novel anti-cancer agents. However, a major bottleneck of this approach is identifying the targets of lead compounds that arise from screens. Here, we coupled the synthesis and screening of fragment-based cysteine-reactive covalent ligands with activity-based protein profiling (ABPP) chemoproteomic approaches to identify compounds that impair colorectal cancer pathogenicity and map the druggable hotspots targeted by these hits. Through this coupled approach, we discovered a cysteine-reactive acrylamide DKM 3-30 that significantly impaired colorectal cancer cell pathogenicity through targeting C1101 on reticulon 4 (RTN4). While little is known about the role of RTN4 in colorectal cancer, this protein has been established as a critical mediator of endoplasmic reticulum tubular network formation. We show here that covalent modification of C1101 on RTN4 by DKM 3-30 or genetic knockdown of RTN4 impairs endoplasmic reticulum and nuclear envelope morphology as well as colorectal cancer pathogenicity. We thus put forth RTN4 as a potential novel colorectal cancer therapeutic target and reveal a unique druggable hotspot within RTN4 that can be targeted by covalent ligands to impair colorectal cancer pathogenicity. Our results underscore the utility of coupling the screening of fragment-based covalent ligands with isoTOP-ABPP platforms for mining the proteome for novel druggable nodes that can be targeted for cancer therapy.

Cascade synthesis of spirooxindole δ-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates

A novel and highly efficient cascade synthesis of spirooxindole δ-lactone derivatives from N-aryl hydroxymethylacrylamides and xanthates in good yields is described. The reaction proceeds through a radical addition/cyclization and ester exchange, in which two new C-C bonds and one C-O bond were formed.

SYNTHESIS OF γ-KETOAMIDES VIA NUCLEOPHILIC ATTACK ON IRON TETRACARBONYL COMPLEXES OF α,β-UNSATURATED AMIDES

Organolithium and Grignard reagents react with the readily-formed iron tetracarbonyl complexes of α,β-unsaturated amides to give γ-ketoamides in good yield via acyl transfer from the metal to the β carbon of the α,β-unsaturated amide.