255864-58-5

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperidinecarboxylic acid, 2-ethynyl-, 1,1-dimethylethyl ester is used as a key intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory and anticancer properties. It contributes to the development of new drugs that can address these health concerns effectively.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Piperidinecarboxylic acid, 2-ethynyl-, 1,1-dimethylethyl ester is utilized as a building block in the creation of compounds that can enhance crop protection and management. Its synthesis capabilities allow for the development of novel agrochemicals that can improve agricultural productivity and pest control.
Used in Organic Synthesis:
1-Piperidinecarboxylic acid, 2-ethynyl-, 1,1-dimethylethyl ester is employed as a versatile reagent in organic synthesis, enabling the construction of complex molecular structures. Its unique properties facilitate the synthesis of a wide range of organic compounds for various applications, including but not limited to pharmaceuticals, agrochemicals, and other specialty chemicals.

InChI:InChI=1/C12H19NO2/c1-5-10-8-6-7-9-13(10)11(14)15-12(2,3)4/h1,10H,6-9H2,2-4H3

Upstream product

• 994-89-8 tributylethynyltin 
• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 56506-90-2 (dibromomethyl)(triphenyl)phosphonium bromide 
• 157634-02-1 tert-butyl 2-formylpiperidine-1-carboxylate 

Downstream Products

• 905706-08-3 tert-Butyl 2-(2-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)ethynyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Conversion of medium-sized lactams to α-vinyl or α-acetylenyl azacycles via N,O-acetal TMS ethers

α-Vinyl or α-acetylenyl azacycles were easily synthesized from 7- to 9-membered lactams and 6- to 9-membered lactams via N,O-acetal trimethylsilyl (TMS) ethers. Organocopper and organostannane reagents afforded reasonable yields for the respective N-acyliminium ion vinylation and acetylenylation intermediates generated from N,O-acetal TMS ethers in the presence of a Lewis acid.

FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS

A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Substituted bicyclic derivatives useful as anticancer agents

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3and R4are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

A one-pot procedure for the synthesis of alkynes and bromoalkynes from aldehydes

Alkynes R-C≡CH were obtained in good yield through a one-pot procedure by a sequence of reactions starting from a Wittig-type condensation of the aldehydes RCHO with the ylide derived from dibromomethyltriphenylphosphonium bromide 5. The same reactions could also be used to prepare the intermediate dibromoalkenes RCH=CBr2, and in certain cases, the bromoalkynes R-C≡CBr.