53857-58-2

Basic information

• Product Name: 7-Bromo-1H-indazole
• Synonyms: 7-BROMO-1H-INDAZOLE;1H-Indazole, 7-bromo-;7-Bromo-1H-indazole 97%
• CAS NO: 53857-58-2
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.03
• Product Categories: Building Blocks;Indazole
• Mol File: 53857-58-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 123-125°
• Boiling Point: 333.8 °C at 760 mmHg
• Flash Point: 155.7 °C
• Appearance: /
• Density: 1.77 g/cm³
• Vapor Pressure: 0.000258mmHg at 25°C
• Refractive Index: 1.727
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.82±0.40(Predicted)
• CAS DataBase Reference: 7-Bromo-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-1H-indazole(53857-58-2)
• EPA Substance Registry System: 7-Bromo-1H-indazole(53857-58-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 53857-58-2(Hazardous Substances Data)

Usage

General Description

7-Bromo-1H-indazole, also known as 1H-Indazole, 7-bromo-, is a brominated derivative of indazole. Indazole is a type of heterocyclic aromatic organic compound that is a fusion of benzene and pyrazole. It is known for its application in the production of different other chemicals, including pharmaceuticals, dyes, agrochemicals, and various types of organic compounds. This particular compound, with a molecular formula of C7H5BrN2, is widely used in the field of organic synthesis, pharmaceuticals, agrochemicals, and dyestuff. Given its chemical properties, it is generally kept at room temperature and should be sealed and stored in a cool, dry place to maintain its shelf life.

InChI:InChI=1/C7H5BrN2/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)

Upstream product

• 52414-97-8 1-bromo-3-methyl-2-nitro-benzene 
• 601-87-6 3-methyl-2-nitroaniline 
• 53848-17-2 2-bromo-6-methylaniline 
• 845751-60-2 (2-bromo-6-methylphenyl)[(1,1-dimethylethyl)thio]diazene 
• 2942-42-9 7-Nitroindazole 
• 1829-34-1 2-hydroxy-3-bromobenzaldehyde 
• 149947-15-9 3-bromo-2-fluorobenzaldehyde 
• 593-56-6 N-methoxylamine hydrochloride 
• 116436-11-4 N-(2-bromo-6-methylphenyl)acetamide 
• 21443-96-9 1H-indazol-7-amine 
• 583-53-9 2,3-dibromobenzene 
• 679795-00-7 7-bromo-3-trimethylsilylindazole 

Downstream Products

• 701910-14-7 7-bromo-2-methyl-2H-indazole 
• 915411-02-8 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 
• 1147015-33-5 7-bromo-1-(propane-2-yl)-1H-indazole 
• 915411-01-7 (1H-indazol-7-yl)boronic acid 
• 701910-15-8 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole 
• 701910-21-6 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazol-3-ylamine 

Relevant articles and documents

Synthesis, antifungal activity and qsar of novel pyrazole amides as succinate dehydrogenase inhibitors

We design and synthesize a series of novel pyrazole amides based on the commercialized fungicides and our previous work. The antifungal activity was tested in vitro by mycelial growth inhibition assay. The results show that all the compounds are of antifungal activities against the tested fungi at different levels. Among them, N-(2-(7-bromo-5-chloro-1H-indazol-1-yl)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (Vk) exhibited higher antifungal activity than boscalid against two fungi. Molecular docking study revealed that the carbonyl oxygen atom of Vk forms two hydrogen bonds toward the hydroxyl hydrogens of TYR58 and TRP173.

3-(4-PIPERIDYL)-IMIDAZOLE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a therapeutic agent which has strong action of adjusting α7 nicotinic acetylcholine receptor(α7 nAChR) and is used in treatment of diseases related to the cholinergic activity of the central nervous system(CNS) and/or the

NOVEL SUBSTITUTED INDAZOLE AND AZA-INDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted indazole and aza-indazole derivatives of Formula (I), wherein R1, R2, R3, R4, Y, A1, A2, A3, A4, X1, X2, X3 and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.