2563-07-7

Usage

Uses

Used in Personal Care Products:
2-Ethoxy-4-methylphenol is used as a fragrance ingredient in personal care products for its ability to enhance and stabilize the scent profile of these products. Its use in this industry is driven by the need for long-lasting and pleasant fragrances that can withstand the wear and tear of daily use.
Used in Cosmetics and Skin Care Products:
In the cosmetics and skin care industry, 2-Ethoxy-4-methylphenol is used as a preservative to prevent the growth of microorganisms that can spoil the product and cause skin irritation or infection. Its antimicrobial properties make it an effective and safe choice for maintaining the integrity and safety of these products.
Used in Soaps:
2-Ethoxy-4-methylphenol is used as a preservative in soaps to extend their shelf life and prevent the growth of bacteria and fungi that can degrade the soap and cause unpleasant odors. Its use in this application ensures that soaps remain effective and safe for use over time.
Used in Pharmaceuticals:
In the pharmaceutical industry, 2-Ethoxy-4-methylphenol is used as a disinfectant and an antiseptic. Its antimicrobial properties make it suitable for use in cleaning and sanitizing surfaces, as well as in the formulation of topical antiseptics for minor cuts and wounds. It is considered safe for use in these applications when used in appropriate concentrations.
Overall, 2-Ethoxy-4-methylphenol is a valuable chemical compound with a wide range of applications in various industries, primarily due to its preservative and antimicrobial properties. Its use in personal care products, cosmetics, soaps, and pharmaceuticals contributes to the safety, efficacy, and longevity of these products, making it an essential component in their formulation.

InChI:InChI=1/C9H12O2/c1-3-11-9-6-7(2)4-5-8(9)10/h4-6,10H,3H2,1-2H3

Upstream product

• 7145-99-5 5-methyl-1,3-benzodioxole 
• 917-64-6 methyl magnesium iodide 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 7664-93-9 sulfuric acid 
• 23385-44-6 2-ethoxy-4-methyl-aniline 
• 2612-56-8 3,4-diethoxy-toluene 
• 64-17-5 ethanol 
• 90-05-1 2-methoxy-phenol 
• 6627-55-0 2-bromo-p-cresol 
• 141-52-6 sodium ethanolate 
• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 

Downstream Products

• 2505-12-6 4-Methyl-5-tert-octyl-2-aethoxy-phenol 
• 2648-92-2 4-Methyl-6-tert-octyl-2-aethoxy-phenol 
• 2612-56-8 3,4-diethoxy-toluene 
• 876760-33-7 4-(2-ethoxy-4-methyl-phenoxy)-2-trifluoromethyl-benzonitrile 
• 2505-09-1 2-Aethoxy-4-methyl-5-tert.-butyl-phenol 
• 2505-16-0 2-Aethoxy-4-methyl-6-tert.-butyl-phenol 
• 856181-13-0 2-ethoxy-6-allyl-4-methyl-phenol 
• 13287-30-4 4-methyl-1,2-phenylene diacetate 
• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 
• 2505-22-8 4-Methyl-5-tert.-butyl-1,2-diaethoxy-benzol 
• 1026087-52-4 {5-[3-(2-ethoxy-4-methyl-phenoxy)-propoxy]-indan-1-yl}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Phosphoric acid-modified commercial kieselguhr supported palladium nanoparticles as efficient catalysts for low-temperature hydrodeoxygenation of lignin derivatives in water

Efficient production of high value-added chemicals and biofuels via low-temperature chemoselective HDO of lignin derivatives in water is still a challenge. Here, we construct a low-cost, active and stable Pd/PCE catalyst using phosphoric acid-modified commercial Celite (PCE) as the support, and this catalyst exhibits excellent activity in low-temperature HDO of vanillin as well as other lignin derivatives in water. The superior catalytic performance is due to the presence of P species on the surface of Pd/PCE, accelerating the selective conversion of the intermediate into the final product. Detailed experimental and mechanistic studies reveal that the rapid conversion of the intermediate to the final product proceeds via a free-radical process in an interfacial microenvironment created by intimate interacting between the P species and Pd NPs. The insights of this work provide a new low-cost catalytic system for efficient production of valuable chemicals and future biofuels from lignin derivatives. This journal is

Encapsulated Ni-Co alloy nanoparticles as efficient catalyst for hydrodeoxygenation of biomass derivatives in water

Catalytic hydrodeoxygenation (HDO) is one of the most promising strategies to transform oxygen-rich biomass derivatives into high value-added chemicals and fuels, but highly challenging due to the lack of highly efficient nonprecious metal catalysts. Herein, we report for the first time of a facile synthetic approach to controllably fabricate well-defined Ni-Co alloy NPs confined on the tip of N-CNTs as HDO catalyst. The resultant Ni-Co alloy catalyst possesses outstanding HDO performance towards biomass-derived vanillin into 2-methoxy-4-methylphenol in water with 100% conversion efficiency and selectivity under mild reaction conditions, surpassing the reported high performance nonprecious HDO catalysts. Impressively, our experimental results also unveil that the Ni-Co alloy catalyst can be generically applied to catalyze HDO of vanillin derivatives and other aromatic aldehydes in water with 100% conversion efficiency and over 90% selectivity. Importantly, our DFT calculations and experimental results confirm that the achieved outstanding HDO catalytic performance is due to the greatly promoted selective adsorption and activation of C=O, and desorption of the activated hydrogen species by the synergism of the alloyed Ni-Co NPs. The findings of this work affords a new strategy to design and develop efficient transition metal-based catalysts for HDO reactions in water.

Auto-Tandem Catalysis with Frustrated Lewis Pairs for Reductive Etherification of Aldehydes and Ketones

Herein we report that a single frustrated Lewis pair (FLP) catalyst can promote the reductive etherification of aldehydes and ketones. The reaction does not require an exogenous acid catalyst, but the combined action of FLP on H2, R-OH or H2O generates the required Br?nsted acid in a reversible, “turn on” manner. The method is not only a complementary metal-free reductive etherification, but also a niche procedure for ethers that would be either synthetically inconvenient or even intractable to access by alternative synthetic protocols.

Practical Ligand-Free Copper-Catalysed Short-Chain Alkoxylation of Unactivated Aryl Bromides

An efficient and practical short-chain alkoxylation of unactivated aryl bromides has been developed with special attention focussed on the applicability of the reaction. Sodium alkoxide is used as the nucleophile, and the corresponding alcohol as the solvent. The reaction requires neither precious metals nor organic ligands. It uses a catalytic system consisting of copper(I) bromide as a catalyst, the corresponding alkyl formate as a noncontaminating cocatalyst, and lithium chloride as an additive. A wide range of substrates and test cases highlight the synthetic utility of the approach. Considering the commercial accessibility and affordability of the feedstocks, this protocol shows promise as a new alternative for the sustainable preparation of aryl alkyl ethers.

One-Pot Defunctionalization of Lignin-Derived Compounds by Dual-Functional Pd50Ag50/Fe3O4/N-rGO Catalyst

Generation of hydrogen from renewable sources and its safe utilization for efficient one-pot upgrading of renewable biofuels are a challenge. Bimetallic PdAg catalyst supported on Fe3O4/nitrogen-doped reduced graphene oxide (N-rGO) were synthesized for hydrogen generation from formic acid with high TOF (497 h-1 at 50 °C), and the hydrogen was subsequently utilized in situ for selective defunctionalization of lignin-derived chemicals with preserved aromatic nature at ambient pressure. Hydrodeoxygenation of aromatic aldehydes and ketones gave excellent yields (99% at 130 °C) with no use of additives. Furthermore, hydrogenolysis of β-O-4 and α-O-4 C-O model compounds produced only two products with high selectivity at 120 °C, which is an efficient and versatile one-pot platform for valorization of lignin biomass.

Mild Deoxygenation of Aromatic Ketones and Aldehydes over Pd/C Using Polymethylhydrosiloxane as the Reducing Agent

Herein, a practical and mild method for the deoxygenation of a wide range of benzylic aldehydes and ketones is described, which utilizes heterogeneous Pd/C as the catalyst together with the green hydride source, polymethylhydrosiloxane. The developed catalytic protocol is scalable and robust, as exemplified by the deoxygenation of ethyl vanillin, which was performed on a 30 mmol scale in an open-to-air setup using only 0.085 mol% Pd/C catalyst to furnish the corresponding deoxygenated product in 93% yield within 3 hours at room temperature. Furthermore, the Pd/C catalyst was shown to be recyclable up to 6 times without any observable decrease in efficiency and it exhibited low metal leaching under the reaction conditions.

Transetherification of guaiacol to o-ethoxyphenol with gamma Al 2O3 as a catalyst in supercritical ethanol

The production of chemicals from lignin and lignin depolymerisation products is a promising alternative route to replace fossil fuels. Transetherification of guaiacol, a lignin derived model compound, to o-ethoxyphenol with γ-Al2O3 as the catalyst in supercritical ethanol has been investigated. The best reaction condition is 280°C for 3 h, giving a yield of 42% with a selectivity of 86%. A reaction pathway is also proposed. Besides, this work provides an example for producing a longer chain ether from a short chain ether.

Facile and regioselective dealkylation of alkyl aryl ethers using niobium(V) pentachloride

A simple and facile method for the cleavage of carbon-oxygen bonds promoted by niobium pentachloride(V) is described. Excellent yields and regioselectivities were observed with various alkyl aryl ethers to give the phenols. NMR studies revealed the formation of monoaryloxy niobium salt(V), and a neighboring-group effect may play a significant role in the regioselectivity. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

A simple and regioselective carbon-oxygen bond cleavage using Niobium(V)

A simple and convenient method for the differentiation of alkoxy groups on aromatic rings is described. Niobium(V) is found to possess a strong Lewis acid property to transform alkyl arylethers smoothly to the corresponding phenols in high yields. The excellent regioselectivity was also observed in dialkoxy benzene derivatives under mild conditions.

Preparation of p-hydroxybenzaldehyde derivatives

A 4-hydroxybenzaldehyde derivative of the formula: STR1 wherein each of R1, R2, R3 and R4 is selected from the group consisting of hydrogen atom, halogen atoms, lower alkyl groups or lower alkoxy groups, which is useful as intermediate for the production of medicines or agricultural chemicals, or as flavor, is produced by the reaction of a p-cresol derivative of the formula: STR2 wherein each of R1, R2, R3 and R4 is as defined above, with oxygen or oxygen-containing gas in the presence of a base and a catalytic amount of cobalt compound or metallic cobalt.