2-Ethoxy-4-methylphenol

Base Information

• Chemical Name: 2-Ethoxy-4-methylphenol
• CAS No.: 2563-07-7
• Molecular Formula: C9H12 O2
• Molecular Weight: 152.193
• Hs Code.: 2909500000
• European Community (EC) Number: 432-030-9,607-762-9
• UNII: 5GZN7D5PRC
• DSSTox Substance ID: DTXSID8062523
• Nikkaji Number: J801.869C
• Wikidata: Q81990083
• Mol file: 2563-07-7.mol

Synonyms:2-Ethoxy-4-methylphenol;2563-07-7;2-ethoxy-p-cresol;Phenol, 2-ethoxy-4-methyl-;Ultravanil;methyl creosol;p-Cresol, 2-ethoxy-;4-Methyl-2-ethoxyphenol;5GZN7D5PRC;SCHEMBL294390;DTXSID8062523;CAA56307;MFCD00043697;2-Ethoxy-4-methylphenol, AldrichCPR;AKOS006229778;BP-11089;TS-02028;CS-0316299;FT-0612200;FT-0612216

Chemical Property of 2-Ethoxy-4-methylphenol

Chemical Property:

• Vapor Pressure: 0.0203mmHg at 25°C
• Melting Point: 28-30°C
• Refractive Index: 1.5230
• Boiling Point: 105-108°C 15mm
• PKA: 10.40±0.18(Predicted)
• Flash Point: 105°C
• PSA: 29.46000
• Density: 1.052g/cm³
• LogP: 2.09930
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 114

Purity/Quality:

99.9% ^*data from raw suppliers

2-Ethoxy-4-methylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xn
• Statements: 36/37/38-43-41-38-22
• Safety Statements: 26-36-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=CC(=C1)C)O

Technology Process of 2-Ethoxy-4-methylphenol

There total 15 articles about 2-Ethoxy-4-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) → 2-ethoxy-4-methylphenol (2563-07-7)

Guidance literature:

With formic acid; In water; at 130 ℃; for 6h; Green chemistry;

DOI:10.1021/acscatal.5b01319

Reference yield: 93.0%

2-bromo-p-cresol (6627-55-0) + sodium ethanolate (141-52-6) → 2-ethoxy-4-methylphenol (2563-07-7)

Guidance literature:

With lithium chloride; copper(I) bromide; formic acid ethyl ester; In ethanol; at 110 ℃; for 4h; Sealed tube;

DOI:10.1002/ejoc.201500500

Reference yield:

ethanol (64-17-5) + 2-methoxy-phenol (90-05-1) → 2-Ethoxyphenol (94-71-3) + 2-ethoxy-4-methylphenol (2563-07-7) + 4-Ethylguaiacol (2785-89-9)

Guidance literature:

With alumina; hydrogen; at 280 ℃; for 5h; under 7500.75 Torr; Time;

DOI:10.1016/j.catcom.2012.10.017

upstream raw materials:

4-hydroxy-3-ethoxybenzaldehyde

5-methyl-1,3-benzodioxole

methyl magnesium iodide

4-methyl-1,2-dihydroxybenzene

Downstream raw materials:

4-methyl-1,2-phenylene diacetate

2-ethoxy-6-allyl-4-methyl-phenol

2-Aethoxy-4-methyl-6-tert.-butyl-phenol

{5-[3-(2-ethoxy-4-methyl-phenoxy)-propoxy]-indan-1-yl}-acetic acid ethyl ester