25632-70-6

Upstream product

• 52392-73-1 5-amino-3,4-diphenylisoxazole 
• 698-16-8 benzohydroximoyl chloride 
• 101-41-7 benzeneacetic acid methyl ester 
• 32569-84-9 ethoxyethynylbenzene 
• 65-85-0 benzoic acid 
• 58929-02-5 ethyl 2,3-diphenyl-3-oxopropanoate 
• 451-40-1 phenyl benzyl ketone 
• 53983-66-7 N-hydroxy-3-hydroxyamino-2,3-diphenyl-propionamidine 

Downstream Products

• 63954-98-3 5-chloro-3,4-diphenylisoxazole 
• 68708-09-8 4-bromo-3,4-diphenyl-2-isoxazolin-5-one 
• 80490-41-1 3,4-diphenyl-4-hydroxy-2-isoxazolin-5-one 
• 75167-73-6 3,4,3',4'-Tetraphenyl-4'H-[2,4']biisoxazolyl-5,5'-dione 
• 1352634-65-1 2,3-diphenyl-5-methyl-1-azabicyclo[3.1.0]hex-2-ene 
• 1352634-56-0 4-(2-methylallyl)-3,4-diphenyl-4H-isoxazol-5-one 
• 78371-22-9 2,2-dimethyl-4,5-diphenyl-3,4-dihydro-2H-pyrrole 
• 1352634-83-3 C₁₉H₁₇NO₂ 
• 1361387-05-4 methyl 2,3-diphenyl-2H-azirine-2-carboxylate 
• 181696-10-6 4-[5-trifluoromethanesulfonoxy-3-phenylisoxazol-4-yl]benzenesulfonamide 
• 181695-83-0 4-[5-hydroxy-3-phenyl-4-isoxazolyl]benzenesulfonamide 

Relevant academic research and scientific papers

One-Pot Reaction of Carboxylic Acids and Ynol Ethers for the Synthesis of β-Keto Esters

An one-pot reaction of carboxylic acids and ynol ethers for the synthesis of β-keto esters has been developed. Under promotion of Ag2O, various carboxylic acids and ynol ethers could transform to α-acyloxy enol esters, which undergo a following DMAP-catalyzed rearrangement to deliver β-keto esters rapidly. This method provides a direct approach to β-keto esters from carboxylic acids without any preactivation. The protocol features mild reaction conditions, broad substrate scope, and the products could be transformed to an array of compounds.

Asymmetric Synthesis of 2H-Azirines with a Tetrasubstituted Stereocenter by Enantioselective Ring Contraction of Isoxazoles

Highly strained 2H-azirines with a tetrasubstituted stereocenter were synthesized by the enantioselective isomerization of isoxazoles with a chiral diene–rhodium catalyst system. The effect of ligands and the coordination behavior support the proposed cat

Atom-Economic Silver-Catalyzed Difunctionalization of the Isocyano Group with Cyclic Oximes: Towards Pyrimidinediones

An unprecedented silver-catalyzed difunctionalization of the isocyano group with cyclic oximes is described. This method allows efficient and atom-economic assembly of a vast array of structurally novel and interesting pyrimidinediones, and tolerates a range of functionalities. The resulting products can be easily converted into some useful compounds. Furthermore, the method can also be applied for the late-stage modification of a few biologically active molecules.

Regioselective catalytic asymmetric C-alkylation of isoxazolinones by a base-free palladacycle-catalyzed direct 1,4-addition

Isoxazolinones constitute a class of heterocycles utilized for the development of novel drug candidates. The cyclic oxime ester motif is also synthetically useful as it contains functional handles which have previously been used to provide access to an assortment of valuable compound classes not easily accessible by alternative approaches. However, asymmetric methods towards isoxazolinones are notoriously scarce. Herein we report the first catalytic asymmetric alkylations of isoxazolinones forming all-C-substituted quaternary stereocenters. The present studies were driven by the question of how to control the regioselectivity in the competition of different nucleophilic positions. The investigation of a direct 1,4-addition uncovered that a sterically demanding palladacycle catalyst directs the reactivity in the absence of a base nearly exclusively to the nucleophilic C atom, while at the same time it allows for high enantioselectivity and TONs up to 1900.

Palladium-catalyzed decarboxylative intramolecular aziridination from 4h-isoxazol-5-ones leading to 1-azabicyclo[3.1.0]hex-2-enes

A decarboxylative intramolecular aziridination reaction of alkene-tethered 4H-isoxazol-5-ones with a palladium/phosphine catalyst gave 1-azabicyclo[3.1.0] hex-2-enes in moderate to high yields (see scheme; dba=dibenzylideneacetone). The resulting N-fused bicyclic aziridines readily reacted with various reagents to afford ring-opening pyrroline derivatives.

Substituted isoxazoles for the treatment of inflammation

A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula (III) wherein R7 is selected from hydroxyl, lower alkyl, carboxyl, halo, lower carboxylalkyl, lower alkoxycarbonylalkyl, lower alkoxyalkyl, lower carboxyalkoxyalkyl, lower haloalkyl, lower haloalkylsulfonyloxy, lower hydroxyalkyl, lower aryl (hydroxylalkyl), lower carboxyaryloxyalkyl, lower alkoxycarbonylaryloxyalkyl, lower cycloalkyl, lower cycloalkylalkyl, and lower aralkyl; and wherein R8 is one or more radicals independently selected from hydrido, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; or a pharmaceutically-acceptable salt thereof.

A New Synthesis of 3,4-Diaryl-5-oxo-4,5-dihydroisoxazoles and Their Transformation to 5-isoxazoles and 5-(2-Aminoethylthio)isoxazoles

A novel method to synthesize 3,4-diaryl-5-oxo-4,5-dihydroisoxazoles by addition of methyl lithio(phenyl)acetates to benzonitrile oxides is described.The isoxazolinones are transformed to 5-isoxazoles and 5-(2-aminoethylthio)isoxazol