25673-61-4Relevant articles and documents
New Synthesis of Diazepam and the Related 1,4-Benzodiazepines by means of Palladium-Catalyzed Carbonylation
Ishikura, Minoru,Mori, Miwako,Ikeda, Toshihito,Terashima, Masanao,Ban, Yoshio
, p. 2456 - 2461 (2007/10/02)
A new synthesis of diazepam (5) was achieved by application of palladium-catalyzed carbonylation to the compound 3 prepared from o-bromoaniline derivative 1 and the amino acid 2, and this procedure was also used for the synthesis of poisonous metabolites