25699-90-5Relevant academic research and scientific papers
Nickel-catalyzed decyanation of inert carbon-cyano bonds
Patra, Tuhin,Agasti, Soumitra,Akanksha,Maiti, Debabrata
supporting information, p. 69 - 71 (2013/02/21)
Nickel catalyzed decyanation of aryl and aliphatic cyanides with hydrosilane as the hydride source has been developed. This method is easy to handle, scalable and can be carried out without a glove box. The method has been applied in the cyanide directed functionalization reaction and α-substitution of benzyl cyanide.
One-Pot N-Arylation of indoles directly from N-arylsulfonylindoles via consecutive deprotection and SnAr reactions with activated aryl halides
Xu, Hui,Fan, Ling-Ling
experimental part, p. 321 - 323 (2009/11/30)
An efficient one-pot step by step t-BuOK-mediated procedure for the synthesis of N-arylindoles has been developed in moderate to good yields. The protocol involves the consecutive deprotection of N-arylsulfonylindoles as latent indoles and subsequent SnAr
Ultrasound-assisted N-arylation of indoles without any catalyst
Xu, Hui,Lv, Lei,Fan, Ling-Ling,He, Xiao-Qiang
experimental part, p. 249 - 256 (2011/04/17)
An efficient method for the ultrasound-assisted N-arylation of indoles with haloarenes in an air atmosphere mediated by Cs2CO3 without any catalyst is reported. N-arylindoles are obtained in moderate to good yields while indoles cross-coupling with activated aryl halides (X = F or Cl). The Japan Institute of Heterocyclic Chemistry.
Synthesis and HIV-1 integrase inhibition activity of some N-arylindoles
Xu, Hui,Liu, Wu-Qing,Fan, Ling-Ling,Chen, Yang,Yang, Liu-Meng,Lv, Lei,Zheng, Yong-Tang
, p. 720 - 722 (2008/12/20)
Eight simple N-arylindoles were designed, synthesized and evaluated as human immunodeficiency virus (HIV)-1 integrase inhibitors in vitro for the first time. Among these compounds, 3b, 3e and 3g demonstrated significant anti-HIV-1 integrase activity. Especially 3b showed the highest anti-HIV-1 integrase activity with EC50 value of 7.88 μg/ml and TI value of 24.61. Meantime, some structure-activity relationships were also observed and will provide a new lead for design and discovery of more potent N-arylindoles as HIV-1 integrase inhibitors.
Microwave-assisted N-arylation of indoles via C(sp2)-N(sp 2) bond formation by aromatic nucleophilic substitution reactions
Xu, Hui,Fan, Ling-Ling
experimental part, p. 298 - 302 (2009/01/31)
Microwave-assisted nucleophilic aromatic substitution on aryl halides with different indoles is described. Moderate to good yields are obtained in short reaction time (25-40 min) when coupling indoles with fluoro- and chloro-substituted aryl halides under catalyst-free conditions.
N-arylation of heterocycles with activated chloro- and fluoroarenes using nanocrystalline copper(II) oxide
Kantam, M. Lakshmi,Yadav, Jagjit,Laha, Soumi,Sreedhar, Bojja,Jha, Shailendra
, p. 1938 - 1942 (2008/09/16)
Nanocrystalline copper oxide was found to be an effective heterogeneous catalyst for the N-arylation of heterocycles with activated chloro- and fluoroarenes using potassium carbonate as base. N-Arylated products were isolated in good to excellent yields. The catalyst can be used for five cycles with almost consistent activity.
A novel and selective method for the N-arylation of indoles mediated by KF/Al2O3
Smith III, William J.,Sawyer, J. Scott
, p. 299 - 302 (2007/10/02)
Indole was reacted with aryl electrophiles in the presence of 37% KF/Al2O3 and catalytic 18-crown-6 in DMSO at 120°C to give selectively 1-arylindoles in fair to excellent yield. Electrophiles containing electronically unfavorable su
