25700-12-3

Usage

Uses

Used in Pharmaceutical Industry:
Pyridine, 3-(1H-pyrazol-1-yl)is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs with diverse therapeutic applications. Its unique structure allows for the creation of molecules with specific biological targets, potentially leading to more effective treatments.
Used in Agrochemical Industry:
In the agrochemical sector, Pyridine, 3-(1H-pyrazol-1-yl)is utilized as a building block for the development of new agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, contributing to increased agricultural productivity.
Used in Fine Chemicals Synthesis:
Pyridine, 3-(1H-pyrazol-1-yl)is also used as a versatile component in the synthesis of fine chemicals. Its presence in these compounds can impart specific properties that are valuable in various industrial applications, such as in the production of dyes, fragrances, and other specialty chemicals.
Used in Drug Discovery and Development:
Pyridine, 3-(1H-pyrazol-1-yl)serves as a valuable tool in drug discovery and development due to its potential pharmacological activities. Researchers can use Pyridine, 3-(1H-pyrazol-1-yl)to design and test new molecules with therapeutic potential, ultimately leading to the creation of innovative treatments for various diseases and conditions.

Upstream product

• 288-13-1 NH-pyrazole 
• 626-55-1 3-Bromopyridine 
• 1120-90-7 3-iodopyridine 
• 1132-27-0 pyridin-3-yl dimethylsulfamate 
• 51581-40-9 3-pyridyl diethylcarbamate 
• 109-00-2 3-HYDROXYPYRIDINE 
• 626-60-8 3-Chloropyridine 
• 372-47-4 3-Fluoropyridine 

Downstream Products

• 1286202-05-8 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)pyridine 
• 28466-02-6 isopropyl-(1-pyridin-3-yl-1H-pyrazol-4-yl)-amine 
• 28466-00-4 1-pyridin-3-yl-1H-pyrazol-4-ylamine 
• 77556-44-6 3-(4-bromo-1H-pyrazol-1-yl)pyridine 

Relevant academic research and scientific papers

N -Arylation of (hetero)arylamines using aryl sulfamates and carbamates via C-O bond activation enabled by a reusable and durable nickel(0) catalyst

An effective and general aryl amination protocol has been developed using a magnetically recoverable Ni(0) based nanocatalyst. This new stable catalyst was prepared on Fe3O4@SiO2 modified by EDTA and investigated by FT-IR, EDX, TEM, XRD, DLS, FE-SEM, XPS, NMR, TGA, VSM, ICP and elemental analysis techniques. The reaction proceeded via carbon-oxygen bond cleavage of (hetero)aryl carbamates and sulfamates under simple and mild conditions without the use of any external ligands. This method demonstrated functional group tolerance in the N-arylation of various nitrogen-containing compounds as well as aliphatic amines, anilines, pyrroles, pyrazoles, imidazoles, indoles, and indazoles with good to excellent yields. Furthermore, the catalyst could be easily recovered by using an external magnetic field and directly reused at least six times without notable reduction in its activity. This journal is

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 1. Evaluation of [3 + 2] Cyclization Strategies to 3-(3-Chloro-1 H-pyrazol-1-yl)pyridine

The evaluation of [3 + 2] cyclization strategies to prepare a key intermediate, 3-(3-chloro-1H-pyrazol-1-yl)pyridine, for the insecticidal candidate tyclopyrazoflor (1) is described. Among the validated strategies, the route involving [3 + 2] cyclization of 3-hydrazinopyridine·2HCl with methyl acrylate was selected for further optimization. This route provided ready access to 3-(3-chloro-1H-pyrazol-1-yl)pyridine in three steps via cyclization, chlorination, and oxidation. Further functionalization of 3-(3-chloro-1H-pyrazol-1-yl)pyridine via nitration, reduction, and amide formation with 3-((3,3,3-trifluoropropyl)thio)propanoic acid followed by ethylation rendered 1 in a total of seven steps.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula (“Formula One”): and processes related thereto.

N-(1-Oxy-2-picolyl)oxalamic acids as a new type of O,O-ligands for the Cu-catalyzed N-arylation of azoles with aryl halides in water or organic solvent

N-(1-Oxy-pyridin-2-ylmethyl)oxalamic acids (L3-L5) were identified as novel efficient ligands for copper-catalyzed C-N cross-coupling of azoles and aryl halides in water. The N-arylation of imidazoles, indoles and pyrazoles proceeded with moderate to excellent yields and complete selectivity over aromatic amines and phenols. Moreover, L5, which is also efficient in organic solvent with low catalyst loading, can be used to promote the N-arylation reactions with water-sensitive materials. The catalytic mechanism was proposed based on the results of several verification experiments which indicated that the ligands as new-type chelators may coordinate to Cu(i) with two oxygen atoms of N-oxide and amide in the coupling process. This journal is

Ligand-free Cu2O-catalyzed cross coupling of nitrogen heterocycles with iodopyridines

A practical and efficient strategy has been developed for the cross coupling of nitrogen heterocycles with halopyridines using ligand-free Cu 2O as catalyst and Cs2CO3 as the base. The protocol is applicable to a series of highly functionalised heterocycles, such as 7-azaindole, indazole, indole, imidazole, pyrrole and pyrazole, affording the N-heteroaryl derivatives in high yields (up to 96%).

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula (“Formula One”): and processes related thereto.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula (“Formula One”): and processes related thereto.

PESTICIDAL COMPOSTIONS AND PROCESSES RELATED THERETO

This document discloses pesticidal molecules having the following formula (“Formula One”): and processes related thereto.

A convenient synthesis of (1 H-azol-1-yl)piperidines

A convenient preparation of 3- and 4-(1H-azol-1-yl)piperidines by arylation of azoles (i.e., pyrazoles, imidazoles, and triazoles) with 3- and 4-bromopyridines and subsequent reduction of the pyridine ring was developed. The method was extended to benzo analogues of the title compounds. Georg Thieme Verlag Stuttgart · New York.