257296-68-7

Basic information

• Product Name: 5-Oxazolecarboxylic acid, 4,5-dihydro-2-phenyl-4-(phenylmethyl)-, methyl ester, (4S,5R)-
• CAS NO: 257296-68-7
• Molecular Formula: C18H17NO3
• Molecular Weight: 295.338
• Mol File: 257296-68-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Oxazolecarboxylic acid, 4,5-dihydro-2-phenyl-4-(phenylmethyl)-, methyl ester, (4S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Oxazolecarboxylic acid, 4,5-dihydro-2-phenyl-4-(phenylmethyl)-, methyl ester, (4S,5R)-(257296-68-7)
• EPA Substance Registry System: 5-Oxazolecarboxylic acid, 4,5-dihydro-2-phenyl-4-(phenylmethyl)-, methyl ester, (4S,5R)-(257296-68-7)

Safety Data

• Hazardous Substances Data: 257296-68-7(Hazardous Substances Data)

Upstream product

• 647852-26-4 methyl (2S,3S)-3-(benzamido)-2-hydroxy-4-phenylbutanoate 
• 186581-53-3 diazomethane 
• 298206-12-9 (4S-trans)-4,5-dihydro-4-benzyl-2-phenyl-oxazoline-5-carboxylic acid 
• 647852-04-8 [(S)-2-Oxo-4-phenyl-3-(trityl-amino)-butyl]-phosphonic acid dimethyl ester 
• 647852-10-6 (E)-(S)-1,5-Diphenyl-4-(trityl-amino)-pent-1-en-3-one 
• 647852-19-5 (S)-2-Oxo-4-phenyl-3-(trityl-amino)-butyric acid methyl ester 
• 18598-80-6 methyl N-trityl-(S)-phenylalaninate 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 63-91-2 L-phenylalanine 

Downstream Products

• 246523-10-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-4-phenylbutanoate 

Relevant articles and documents

A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates

Practical synthetic routes to β-amino-α-hydroxy carboxylates (AHC) have been developed from amino acids. Reduction of β-amino-α- keto esters 6 with NaBH4 was found to give anti-AHCs 7 in high de, which were efficiently converted to the corresponding syn-AHCs 8 via oxazolidine ring 10 formation.