647852-26-4

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 18598-80-6 methyl N-trityl-(S)-phenylalaninate 
• 647852-04-8 [(S)-2-Oxo-4-phenyl-3-(trityl-amino)-butyl]-phosphonic acid dimethyl ester 
• 647852-10-6 (E)-(S)-1,5-Diphenyl-4-(trityl-amino)-pent-1-en-3-one 
• 647852-19-5 (S)-2-Oxo-4-phenyl-3-(trityl-amino)-butyric acid methyl ester 
• 98-88-4 benzoyl chloride 
• 63-91-2 L-phenylalanine 

Downstream Products

• 246523-10-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-4-phenylbutanoate 
• 257296-68-7 methyl (4S,trans)-4,5-dihydro-2-benzyl-4-phenyl-5-carboxylate 

Relevant academic research and scientific papers

Efficient enantioselective synthesis of α-hydroxy-β-amino acids using the Claisen and Curtius rearrangements

Highly enantioselective and facile synthesis of α-hydroxy-β- amino acids has been achieved using the Claisen and Curtius rearrangements as key reactions. Chiral allylic alcohols were employed, which can be prepared by asymmetric catalysis in both E- and Z

A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates

Practical synthetic routes to β-amino-α-hydroxy carboxylates (AHC) have been developed from amino acids. Reduction of β-amino-α- keto esters 6 with NaBH4 was found to give anti-AHCs 7 in high de, which were efficiently converted to the corresponding syn-AHCs 8 via oxazolidine ring 10 formation.