25756-29-0

Basic information

• Product Name: 1-cyclohexyl-N-methyl-methanamine
• Synonyms: 1-cyclohexyl-N-methyl-methanamine;N-Methylcyclohexylmethanamine;(cyclohexylmethyl)methylamine(SALTDATA: HCl);(CyclohexylMethyl)(Methyl)aMine;N-Methyl-cyclohexaneMethanaMine;Cyclohexanemethanamine, N-methyl-
• CAS NO: 25756-29-0
• Molecular Formula: C₈H₁₇N
• Molecular Weight: 127.23
• Mol File: 25756-29-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: -15°C (estimate)
• Boiling Point: 166.06°C (estimate)
• Flash Point: 41.3°C
• Appearance: /
• Density: 0.8455 (estimate)
• Vapor Pressure: 2.34mmHg at 25°C
• Refractive Index: 1.4503 (estimate)
• PKA: 10.98±0.10(Predicted)
• CAS DataBase Reference: 1-cyclohexyl-N-methyl-methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclohexyl-N-methyl-methanamine(25756-29-0)
• EPA Substance Registry System: 1-cyclohexyl-N-methyl-methanamine(25756-29-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• Hazardous Substances Data: 25756-29-0(Hazardous Substances Data)

Usage

General Description

1-cyclohexyl-N-methyl-methanamine, also known as CW-1, is an organic compound with the chemical formula C8H17N. It is a colorless liquid at room temperature and is highly soluble in water. 1-cyclohexyl-N-methyl-methanamine is commonly used as a precursor in the synthesis of pharmaceuticals and other organic compounds. It is also used as a chelating agent in metal ion coordination chemistry. The chemical is considered to have low toxicity, but proper safety measures should be taken when handling it due to its potential to cause irritation to the skin, eyes, and respiratory tract.

InChI:InChI=1/C8H17N/c1-9-7-8-5-3-2-4-6-8/h8-9H,2-7H2,1H3

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 124-38-9 carbon dioxide 
• 3218-02-8 cyclohexylmethylamine 
• 56700-67-5 tert-butyl N-cyclohexylmethylcarbamate 
• 1239325-65-5 tert-butyl N-(cyclohexylmethyl)-N-methylcarbamate 
• 88070-48-8 N-methylbenzamide 
• 74-89-5 methylamine 
• 2043-61-0 cyclohexanecarbaldehyde 
• 931-51-1 cyclohexylmagnesiumchloride 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 6830-84-8 N-methylcyclohexanecarboxamide 
• 19885-73-5 (E)-1-cyclohexyl-N-methylmethanimine 

Downstream Products

• 735351-38-9 N-cyc!ohexylmethyl-N-methyl-4-nitrobenzamide 
• 1250965-30-0 C₁₉H₂₈ClN₃O₃ 
• 666861-02-5 3-methyl-1,3-diazaspiro[4.5]decan-2-one 
• 911114-86-8 (3S,4R)-3-[(cyclohexylmethyl-methyl-carbamoyloxy)-methyl]-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Titanium(III)-Oxo Clusters in a Metal-Organic Framework Support Single-Site Co(II)-Hydride Catalysts for Arene Hydrogenation

Titania (TiO2) is widely used in the chemical industry as an efficacious catalyst support, benefiting from its unique strong metal-support interaction. Many proposals have been made to rationalize this effect at the macroscopic level, yet the underlying molecular mechanism is not understood due to the presence of multiple catalytic species on the TiO2 surface. This challenge can be addressed with metal-organic frameworks (MOFs) featuring well-defined metal oxo/hydroxo clusters for supporting single-site catalysts. Herein we report that the Ti8(μ2-O)8(μ2-OH)4 node of the Ti-BDC MOF (MIL-125) provides a single-site model of the classical TiO2 support to enable CoII-hydride-catalyzed arene hydrogenation. The catalytic activity of the supported CoII-hydride is strongly dependent on the reduction of the Ti-oxo cluster, definitively proving the pivotal role of TiIII in the performance of the supported catalyst. This work thus provides a molecularly precise model of Ti-oxo clusters for understating the strong metal-support interaction of TiO2-supported heterogeneous catalysts.

Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs

Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or aryl sulfone motifs were synthesized and tested towards serine hydroxymethyltransferase (SHMT), a key enzyme of the folate cycle. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target, as well as PfNF54 strains in cell-based assays in the low nanomolar range (18–56 nm). Seven co-crystal structures with P. vivax (Pv) SHMT were solved at 2.2–2.6 ? resolution. We observed an unprecedented influence of the torsion angle of ortho-substituted biphenyl moieties on cell-based efficacy. The peculiar lipophilic character of the sulfonyl moiety was highlighted in the complexes with aryl sulfonamide analogues, which bind in their preferred staggered orientation. The results are discussed within the context of conformational preferences in the ligands.

Heterogeneous CeO2 catalyst for the one-pot synthesis of organic carbamates from amines, CO2 and alcohols

Heterogeneous CeO2 catalyst can catalyze the one-pot synthesis of methyl benzylcarbamate from benzylamine, CO2 and methanol. The yield of methyl benzylcarbamate reached 92% at >99% benzylamine conversion and 92% benzylamine-based selectivity even in the absence of the dehydrating agents. The catalyst is reusable after the calcination at 873 K for 3 h. Various carbamates can be synthesized with good yield and high selectivity by the reaction of amines + CO2 + alcohols over CeO2. The main formation route of methyl benzylcarbamate is suggested to be the reaction of dimethyl carbonate or the precursor of dimethyl carbonate formation with benzylamine.