257933-87-2

Upstream product

• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 237423-46-0 3-isobutylamino-dihydro-thiophen-2-one 

Downstream Products

• 257933-88-3 4-benzylsulfanyl-2-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-butyric acid methyl ester 
• 478957-90-3 2-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-4-(pyridin-3-ylmethylsulfanyl)-butyric acid methyl ester 
• 257933-89-4 4-benzylsulfanyl-N-tert-butoxy-2-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-butyramide 
• 237423-47-1 4-(Benzylsulfanyl)-2-{isobutyl-[(4-methoxyphenyl)sulphonyl]amino}butanoic acid 
• 478964-55-5 2-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-4-(pyridin-3-ylmethylsulfanyl)-N-trityloxy-butyramide 
• 463300-58-5 2-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-4-phenylmethanesulfonyl-butyric acid methyl ester 
• 478963-06-3 2-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-4-(pyridin-3-ylmethylsulfanyl)-butyric acid 
• 478959-47-6 3-(4-methoxy-benzenesulfonyl)-5-methyl-2-(2-pentafluorophenylmethylsulfanyl-ethyl)-hexanoic acid methyl ester 
• 478958-02-0 2-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-4-(thiophen-3-ylmethylsulfanyl)-butyric acid methyl ester 

Relevant academic research and scientific papers

Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.

A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found.

N-aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: Further probing of the S1, S1′, and S2′ pockets

A series of N-arylsulfonyl S-alkyl homocysteine hydroxamic acids were synthesized with variations in three subsites corresponding to P1, P1′, and P2′. Enzyme assays with a variety of MMPs revealed activity at the low nanomolar level.

Hydroxamic acid compounds

A compound selected from those of formula (I): wherein: R1 represents optionally substituted alkyl, acyl, cycloalkyl, aryl, aminocarbonylalkyl, or heterocycle, R2 represents alkylene, R3 represents X or Y as defined in the description, R4 represents-either alkyl, cycloalkyl, aryl, arylalkyl, cycloalkylalkyl, heterocycloalkylene, or heterocycle when R3 represents Y, or biaryl, arylheteroaryl or heteroarylaryl, when R3 represents X or Y, their isomers and also pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful as metalloprotease inhibitors in the treatment of cancers.