Bioorganic and medicinal chemistry letters p. 1691 - 1696 (1999)
Update date:2022-07-30
Topics:
Hanessian
Bouzbouz
Boudon
Tucker
Peyroulan
A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found.
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Doi:10.1016/S0040-4039(99)02030-4
(1999)Doi:10.1021/ja01514a040
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