257933-88-3Relevant academic research and scientific papers
N-aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: Further probing of the S1, S1′, and S2′ pockets
Hanessian,Moitessier,Gauchet,Viau
, p. 3066 - 3073 (2007/10/03)
A series of N-arylsulfonyl S-alkyl homocysteine hydroxamic acids were synthesized with variations in three subsites corresponding to P1, P1′, and P2′. Enzyme assays with a variety of MMPs revealed activity at the low nanomolar level.
Hydroxamic acid compounds
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, (2008/06/13)
A compound selected from those of formula (I): wherein: R1 represents optionally substituted alkyl, acyl, cycloalkyl, aryl, aminocarbonylalkyl, or heterocycle, R2 represents alkylene, R3 represents X or Y as defined in the description, R4 represents-either alkyl, cycloalkyl, aryl, arylalkyl, cycloalkylalkyl, heterocycloalkylene, or heterocycle when R3 represents Y, or biaryl, arylheteroaryl or heteroarylaryl, when R3 represents X or Y, their isomers and also pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful as metalloprotease inhibitors in the treatment of cancers.
Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.
Hanessian,Bouzbouz,Boudon,Tucker,Peyroulan
, p. 1691 - 1696 (2007/10/03)
A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found.
