258289-46-2

Upstream product

• 258289-42-8 1-(3-benzyloxy-2-ethenyl-5-methoxy-4-methylphenyl)ethane-1,2-diol 
• 258289-41-7 3-benzyloxy-2-ethenyl-5-methoxy-4-methylbenzaldehyde 
• 258289-39-3 3-benzyloxy-2-hydroxy-5-methoxy-4-methylbenzaldehyde 
• 105104-09-4 2-benzyloxy-4-methoxy-3-methylbenzaldehyde 
• 7149-92-0 2,4-dimethoxy-3-methylbenzaldehyde 
• 54700-36-6 2-hydroxy-4-methoxy-3-methylbenzaldehyde 
• 258289-45-1 2-benzyloxy-4-[2-(tert-butyldimethylsilyloxy)-1-(hydroxyimino)ethyl]-3-ethenyl-6-methoxytoluene 

Downstream Products

• 73777-65-8 (5,8-dihydro-7-methoxy-6-methyl-5,8-dioxo-1-isoquinolinyl)methyl (2Z)-2-methyl-2-butenoate 
• 258289-51-9 (5-hydroxy-7-methoxy-6-methylisoquinol-1-yl)methyl acetate 
• 258289-49-5 (5-benzyloxy-7-methoxy-6-methylisoquinol-1-yl)methyl acetate 
• 258289-50-8 (5-benzyloxy-7-methoxy-6-methylisoquinol-1-yl)methyl propionate 
• 258289-47-3 5-benzyloxy-1-hydroxymethyl-7-methoxy-6-methylisoquinoline 

Relevant academic research and scientific papers

Syntheses of the antibiotic alkaloids renierone, mimocin, renierol, renierol acetate, renierol propionate, and 7-methoxy-1,6-dimethylisoquinoline-5, 8-dione

The total synthesis of renierone, mimocin, renierol, renierol acetate, renierol propionate, and 7-methoxy-1,6-dimethylisoquinoline-5,8-dione was successfully achieved by the regioselective oxidation of 5-oxygenated isoquinoline. The synthetic method of the 5-oxygenated isoquinoline is based on the thermal electrocyclic reaction of 1-azahexatriene system involving the benzene 1,2-bond.

New regioselective total syntheses of antibiotic renierol, renierol acetate, and renierol propionate from the 5-oxygenated isoquinoline

New total syntheses of renierol (3), renierol acetate (4), and renierol propionate (5) were completed by the synthesis of 5-oxygenated isoquinoline (6) based on the thermal electrocyclic reaction of the 1-azahexatriene system followed by regioselective ox