2584-64-7Relevant academic research and scientific papers
Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: Synthesis of disubstituted heterocycles
Langille, Neil F.,Dakin, Les A.,Panek, James S.
, p. 2485 - 2488 (2007/10/03)
(Matrix presented) This paper describes Sonogashira cross-coupling of functionalized 2-, 4-, and 5-trifloyl oxazoles and thiazoles with terminal alkynes. This methodology has been extended to 2,4-ditrifloylthiazoles, which results in regioselective cross-coupling at the C2-position of the thiazole. The resulting 2-alkynyl-4-trifloylthiazoles are effective electrophiles in a second palladium(0)-mediated cross-coupling reaction.
A total synthesis and structural aspects of racemic 8-oxygenated tetracyclines
Glatz,Helmchen,Muxfeldt,et al.
, p. 2171 - 2181 (2007/10/04)
A stereoselective total synthesis of the first 8-oxygenated tetracycline derivatives 43 and 4 is described. Key steps for the construction of the tetracycline skeleton are the condensation of the tetralone aldehyde 24 with the thiazolone 32 followed by co
