25856-03-5

Upstream product

• 6552-66-5 3-(4-methoxyphenyl)-1-p-tolylprop-2-en-1-one 
• 65418-72-6 1-(4-methoxyphenyl)-3-(4-methylphenyl)-2-ethynyl-1-one 
• 32045-76-4 2,3-dibromo-3-(4-methoxyphenyl)-1-(4-methylphenyl)-propan-1-one 

Downstream Products

• 37613-33-5 5-(4-methoxyphenyl)-3-(p-tolyl)isoxazole 
• 65205-51-8 3-(4′-methoxyphenyl)-5-(4″-methylphenyl)isoxazole 
• 22693-32-9 4-methylbenzoyl azide 
• 3532-17-0 4-methoxybenzoyl azide 
• 33425-19-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethane-1,2-dione 
• 193486-28-1 1-(4-methoxyphenyl)-2,2-dimethyl-3-(4-methylphenyl)-propane-1,3-dione 

Relevant academic research and scientific papers

A metal-free strategy for the cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol

Here, we report a metal-free approach for the construction of methylene-bridged bis-1,3-dicarbonyl compounds via cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol. In addition, we have extended this methodology to synthesize tetra-substituted pyridine derivatives using 1,3-dicarbonyl, 2-methoxyethanol and NH4OAc in one step. The key advantages include accepting a wide range of substrates, utilizing O2 as the sole oxidant, and synthesizing biologically active compounds such as 1,4-dihydropyridine and pyrazole. This journal is

Clemmensen reduction. XII The synthesis and acidolysis of some diaryl-substituted cyclopropane-1,2-diols. The possible involvement of a cyclopropyl cation

The generation of a number of 1,2-diarylcyclopropane-1,2-diols is reported. Reaction of these in situ with acid gives, primarily, an α,β-unsaturated ketone in which the aryl substituent attached to the double bond is that which is best able to stabilize a benzylic cation. It is proposed that the reaction proceeds by O-protonation of the cyclopropane- 1,2-diol, followed by loss of water and opening of the resulting cyclopropyl cation and final deprotonation. Such initial O-protonation contrasts with the C-protonation normally observed in the acidolysis of cyclopropanols and other dialkyl- and alkylaryl-cyclopropane-1,2-diols.

Synthesis and antimicrobial activity of 1-(4-chlorophenyl)-3-(4-methoxy/3,4-dimethoxyphenyl)propan-1,3-diones and their 2-analogs

The condensation of substituted acetophenones 1-5 with 4-methoxy- or 3,4-dimethoxy-benzaldehyde (6,7) in ethanolic NaOH gives the corresponding substituted 2-propen-1-ones (8-17) which on bromination yields substituted propan-1-ones (18-27).Refluxing of 1