65205-51-8

Upstream product

• 25856-03-5 1-(4-methoxy-phenyl)-3-p-tolyl-propane-1,3-dione 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 766-97-2 4-n-methylphenylacetylene 
• 104-87-0 4-methyl-benzaldehyde 
• 65418-75-9 3-(4-methoxyphenyl)-1-(4-methylphenyl)prop-2-yn-1-one 
• 768-60-5 4-methoxyphenylacetylen 
• 3717-21-3 p-methoxyl benzaldoxime 

Downstream Products

• 65204-51-5 4-chloro-5-(4-{4-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-styryl}-phenyl)-2-phenyl-2H-[1,2,3]triazole 
• 65204-55-9 4-(4-{4-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-styryl}-phenyl)-2,5-diphenyl-2H-[1,2,3]triazole 
• 65204-63-9 2-(4-{4-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-styryl}-phenyl)-4,5-diphenyl-2H-[1,2,3]triazole 
• 65965-63-1 2-(4-{4-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-styryl}-phenyl)-[1,2,4]triazolo[1,5-a]pyridine 
• 65204-59-3 2-(4-{4-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-styryl}-phenyl)-4-phenyl-2H-[1,2,3]triazole 
• 65204-47-9 4-(4-{4-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-styryl}-phenyl)-2-phenyl-2H-[1,2,3]triazole 
• 71944-13-3 3-(4-methoxy-phenyl)-5-{4-[4-(3-phenyl-pyrazol-1-yl)-styryl]-phenyl}-isoxazole 
• 71944-20-2 5-{4-[4-(2,5-diphenyl-2H-pyrazol-3-yl)-styryl]-phenyl}-3-(4-methoxy-phenyl)-isoxazole 
• 71944-17-7 3-(4-methoxy-phenyl)-5-{4-[4-(1-phenyl-1H-pyrazol-3-yl)-styryl]-phenyl}-isoxazole 
• 343617-89-0 5-(4-bromomethyl-phenyl)-3-(4-methoxy-phenyl)-isoxazole 
• 343617-91-4 4-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-benzaldehyde 
• 343768-82-1 4-chloro-N-{4-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-benzylidene}-aniline 

Relevant academic research and scientific papers

Unusual Reactivity of 4-Vinyl Isoxazoles in the Copper-Mediated Synthesis of Pyridines, Employing DMSO as a One-Carbon Surrogate

An efficient protocol for the synthesis of nicotinate derivatives and tetrasubstituted pyridines through a copper-mediated cleavage of isoxazoles has been developed. The highlight of the work is the observation of an unusual reactivity of 4-vinyl isoxazoles under the reaction conditions. DMSO serves as a one-carbon surrogate generating an active methylene group during the reaction to form two C-C bonds. This protocol provides a facile and an expeditious approach for the assembly of densely substituted N-heterocyclic compounds.

Preparation of 3,5-disubstituted pyrazoles and isoxazoles from terminal alkynes, aldehydes, hydrazines, and hydroxylamine

The reaction of terminal alkynes with n-BuLi, and then with aldehydes, followed by the treatment with molecular iodine, and subsequently hydrazines or hydroxylamine provided the corresponding 3,5-disubstituted pyrazoles or isoxazoles in good yields with high regioselectivity, through the formations of propargyl secondary alkoxides and α-alkynyl ketones. The present reactions are one-pot preparation of 3,5-disubstituted pyrazoles from terminal alkynes, aldehydes, molecular iodine, and hydrazines, and 3,5-disubstituted isoxazoles from terminal alkynes, aldehydes, molecular iodine, and hydroxylamine.

Ruthenium-catalyzed cycloaddition of nitrile oxides and alkynes: Practical synthesis of isoxazoles

(Chemical Equation Presented) 3,4-Disubstituted and 3,4,5-trisubstituted isoxazoles have been formed from alkynes and nitrile oxides in a ruthenium(II)-catalyzed process (see scheme; cod=cycloocta-l,5-diene, Cp=C5Me5). These reaction