25871-25-4

Basic information

• Product Name: (4-chlorophenyl)(quinoxalin-2-yl)methanone
• Synonyms: (4-chlorophenyl)(quinoxalin-2-yl)methanone
• CAS NO: 25871-25-4
• Molecular Weight: 268.702
• Mol File: 25871-25-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (4-chlorophenyl)(quinoxalin-2-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl)(quinoxalin-2-yl)methanone(25871-25-4)
• EPA Substance Registry System: (4-chlorophenyl)(quinoxalin-2-yl)methanone(25871-25-4)

Safety Data

• Hazardous Substances Data: 25871-25-4(Hazardous Substances Data)

Upstream product

• 91-19-0 2,3-diethynylquinoxaline 
• 104-86-9 4-chlorobenzylamine 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 1448-87-9 2-chloroquinoxaline 
• 104-88-1 4-chlorobenzaldehyde 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 105702-44-1 (S)-1-(4-Chloro-phenyl)-2-((S)-methanesulfinyl)-1-quinoxalin-2-yl-ethanol 
• 105702-44-1 (S)-1-(4-Chloro-phenyl)-2-((R)-methanesulfinyl)-1-quinoxalin-2-yl-ethanol 
• 17286-63-4 2-(4-chlorophenyl)quinoxaline 
• 74-11-3 para-chlorobenzoic acid 
• 91-19-0 2,3-diethynylquinoxaline 
• 105702-44-1 1-(4-Chloro-phenyl)-2-methanesulfinyl-1-quinoxalin-2-yl-ethanol 

Relevant articles and documents

Nickel-catalyzed electrochemical Minisci acylation of aromatic N-heterocycles with α-keto acids via ligand-to-metal electron transfer pathway

A nickel-catalyzed electrochemical methodology for the Minisci acylation of aromatic electron-deficient heterocycles with α-keto acids has been developed. The reaction is performed in an undivided cell under constant current conditions, featuring broad scope of substrates and avoiding the conventional utilization of silver-based catalysts in conjunction with excess amount of oxidants. Cyclic voltammetric analysis disclosed that a ligand-to-metal electron transfer process may be involved in the generation of the key acyl radicals.

Regiospecific benzoylation of electron-deficient n -heterocycles with methylbenzenes via a minisci-type reaction

A regioselective cross-dehydrogenative coupling between electron-deficient N-heterocycles (isoquinoline, quinolines, and quinoxalines) and methylbenzenes leading to regiospecific C-aroylation has been accomplished using AlCl3 as the catalyst in

Quinoxalines. XXII. Aryl Migration of 2-Aroylquinoxalines to 2-Arylquinoxalines

The reaction of 2-aroylquinoxalines (1) with sodium hydroxide in dimethyl sulfoxide (DMSO) was found to result in aryl migration, fission of the C2-C=O bond, and addition of DMSO to the C=O group, giving 2-arylquinoxalines (2), quinoxaline (4), aroic acids (5), and α-aryl-α-(methylsulfinylmethyl)-2-quinoxalinemethanols (6).Compounds 6 could be separatedinto two racemates, (αR*,SR*)-6, and (αR*,SS*)-6.In order to establish the generality of the aryl migration, other aroylated aromatic heterocycles were examined. 3-Aroylpyridopyrazines (7) and 1-benzoyl-4-isoquinolinecarbonitrile (10) both underwent similar aryl migration to give 3-arylpyridopyrazines (14) and 1-phenyl-4-isoguinolinecarbonitrile (18), respectively.On the other hand, the reaction of 1-benzoylisoquinoline (9) and 2-benzoilquinoline (11) resulted not in migration, but in the addition of DMSO to give 1-isoquinolinemethanol (16) and 2-quinolinemethanol derivatives (20), respectively.In the case of 1-benzoylphtalazine (8), migration did not occur, but instead 4-benzoyl-1(2H)-phthalazinone (15) was formed.Keywords - 2-aroylquinoxaline; 2-arylquinoxaline; 2-quinoxalinemethanol; aryl migration; racemate; 3-arylpyridopyrazine; 1-isoquinolinemethanol; 2-quinolinemethanol; 1-phenyl-4-isoquinolinecarbonitrile; 4-benzoyl-1(2H)-phthalazinone