17286-63-4

Upstream product

• 67-68-5 dimethyl sulfoxide 
• 25871-25-4 (4-chlorophenyl)(quinoxalin-2-yl)methanone 
• 95-54-5 1,2-diamino-benzene 
• 25755-85-5 3-(4-chlorophenyl)isoxazol-5-(4H)-one 
• 2788-86-5 4-Chlorostyrene oxide 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 91-19-0 2,3-diethynylquinoxaline 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 932022-91-8 N,N-bis(4-chlorinephenacyl)aniline 
• 932022-93-0 N,N-bis(4-chlorinephenacyl)-4-methylaniline 
• 518068-75-2 2,4-dinitro-benzenesulfonic acid 2-(4-chloro-phenyl)-2-oxo-ethyl ester 
• 3750-07-0 2-(4-chlorophenyl)-2-oxoacetaldehyde oxime 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 1252876-04-2 (S)-2-(4-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 27993-84-6 2-(4-chloro-2-nitrophenyl)quinoxaline 
• 1289167-33-4 (R)-2-(4-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 1420295-63-1 2-(4-chlorophenyl)-3-(dimethoxymethyl)quinoxaline 
• 1327154-13-1 2-(4-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 1444302-49-1 2-(4-chloro-2-fluorophenyl)quinoxaline 

Relevant academic research and scientific papers

Green synthesis of novel quinoxaline sulfonamides with antibacterial activity

A facile and efficient method was investigated for the synthesis of different quinoxalines by the reaction of o-phenylene diamine and 2-bromoacetophenones. This procedure was carried out in ethanol under catalyst-free conditions. Several sulfonamides were synthesized from 2-(4-methoxyphenyl)-quinoxaline in two steps. At first chlorosulfonation of 2-(4-methoxyphenyl) quinoxaline was done using chlorosulfonic acid and led to 2-methoxy-5-quinoxalin-2-yl-benzenesulfonyl chloride. Then quinoxaline sulfonamides were synthesized by the reaction of quinoxaline sulfonyl chloride with different aromatic amines under solvent-free conditions. All the products were obtained in excellent yields after an easy work-up and were evaluated for antibacterial activities against Staphylococcus spp. and Escherichiacoli bacteria.

Direct and catalytic synthesis of quinoxaline derivatives from epoxides and ene-1,2-diamines

We describe here a new synthesis of quinoxaline derivatives by a Bi-catalyzed oxidative coupling of epoxides and ene-1,2-diamines.

Mechanically induced transition metal free C(sp2)-H arylation of quinoxalin(on)es with diaryliodonium salts and piezoelectric BaTiO3

A transition metal free mechanically induced C(sp2)-H arylation of quinoxalin(on)es is described. In this study, diaryliodonium salts generate aryl radical by planetary ball milling, with the assist of piezoelectric material BaTiO3. A broad range of functional groups are tolerated to give products in moderate to good yields via radical mechanism.

Silica supported dodecatungstophosphoric acid (DTP/SiO2): An efficient and recyclable heterogeneous catalyst for rapid synthesis of quinoxalines

A facile synthesis of quinoxalines by the cyclocondensation of substituted phenacyl bromides with o-pheneylenediamines using silica-supported dodecatungstophosphoric acid (DTP/SiO2) as a recyclable heterogeneous catalyst is unveiled in this res

Tetrabutylammonium Bromide-Catalyzed Transfer Hydrogenation of Quinoxaline with HBpin as a Hydrogen Source

A metal-free environmentally benign, simple, and efficient transfer hydrogenation process of quinoxaline has been developed using the HBpin reagent as a hydrogen source. This reaction is compatible with a variety of quinoxalines offering the desired tetrahydroquinoxalines in moderate-to-excellent yields with Bu4NBr as a noncorrosive and low-cost catalyst.

A heterogeneous catalytic strategy for facile production of benzimidazoles and quinoxalines from primary amines using the Al-MCM-41 catalyst

This study reports a straightforward heterogeneous catalytic (Al-MCM-41) approach to synthesize nitrogen heterocycle moieties from primary amines under solvent-free conditions. The Al-MCM-41 catalyst was prepared using a hydrothermal method and characterized by various analytical techniques. The probability and limitations of the catalytic methodology were presented with various substrates. The catalytic method grants an attractive route to a wide variety of benzimidazole and quinoxaline moieties with good to excellent yields. The gram scale reaction and reusability (up to five cycles) of the Al-MCM-41 catalyst would greatly benefit industrial applications. This journal is

Visible light promoted tandem dehydrogenation-deaminative cyclocondensation under aerobic conditions for the synthesis of 2-aryl benzimidazoles/quinoxalines fromortho-phenylenediamines and arylmethyl/ethyl amines

Visible light promoted domino synthesis of 2-aryl benzimidazoles is reported through the reaction ofortho-phenylenediamines and arylmethyl amines under aerobic conditions. The methodology has wide substrate scope and tolerates a wide range of functional groups affording the products in high yields. The use of arylethyl amines instead of arylmethyl amines gives 2-aryl quinoxalines.

NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy

A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcohols are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.

Iridium-Catalyzed [4+2] Annulations of β-Keto Sulfoxonium Ylides and o-Phenylenediamines: Mild and Facile Synthesis of Quinoxaline Derivatives

A synthetic method for quinoxaline derivatives from the [4+2] annulation of β-keto sulfoxonium ylides and o-phenylenediamine by using (Cp*IrCl2)2 catalyst is described. This novel protocol features mild reaction conditions, moderate to excellent yields, wide substrate scope, and high functional-group compatibility. Moreover, this cyclization strategy was successfully applied in late-stage modification for structurally complex bioactive compounds.

Novel green synthesis method for efficiently synthesizing quinoxaline derivative through transition metal catalyzed carbene insertion/cyclization reaction

The invention discloses a novel green synthesis method for efficiently synthesizing a C-N bond and a quinoxaline derivative through a transition metal catalyzed carbene insertion/cyclization reactionby taking pure water as a solvent and sulfur ylide as a carbene donor. Compared with the traditional method, the method has the advantages that the raw materials are easy to obtain, the steps are simple, the use of toxic organic solvents is avoided and the method is a mild, quick, simple, convenient, effective and environment-friendly method for preparing the quinoxaline mother ring and has a wideapplication prospect.