259137-53-6

Upstream product

• 491-19-0 1,4-anhydro-D-ribitol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 215031-98-4 2(R)-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-(3S,4S)-diol 

Downstream Products

• 259137-54-7 2(R)-(tert-butyldimethylsilyloxymethyl)-4(R)-azidotetrahydrofuran-3(S)-ol 
• 367270-92-6 tert-butyl-(2,2-dioxo-tetrahydro-2λ⁶-furo[3,4-d][1,3,2]dioxathiol-4-ylmethoxy)-diphenyl-silane 
• 259137-67-2 1-[(3R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-3-((E)-3-methoxy-2-methyl-acryloyl)-urea 
• 259137-60-5 4(R)-[{(3-ethoxy-1-oxo-2-propenyl)aminocarbonyl}amino]-2(R)-(tert-butyldimethylsilyloxymethyl)-3(S)-(tert-butyldiphenylsilyloxy)tetrahydrofuran 
• 259137-59-2 2(R)-(tert-butyldimethylsilyloxymethyl)-3(S)-(tert-butyldiphenylsilyloxy)-4(R)-aminotetrahydrofuran 
• 259137-71-8 2(R)-(tert-butyldimethylsilyloxymethyl)-3(S)-(tert-butyldiphenylsilyloxy)-4(R)-azidotetrahydrofuran 
• 259137-56-9 2(R)-(tert-butyldimethylsilyloxymethyl)-4(R)-(5-amino-6-chloro-4-pyrimidylamino)tetrahydrofuran-3(S)-ol 
• 259137-70-7 4(R)-(6-chloro-9H-purin-9-yl)-2(R)-(tert-butyldiphenylsilyloxymethyl)tetrahydrofuran-3(S)-ol 
• 259137-62-7 4(R)-[3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-2(R)-(hydroxymethyl)-3(S)-(tert-butyldiphenylsilyloxy)tetrahydrofuran 
• 259137-68-3 Benzoic acid (2R,3S,4R)-3-methanesulfonyloxy-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 259137-55-8 2(R)-(tert-butyldimethylsilyloxymethyl)-4(R)-aminotetrahydrofuran-3(S)-ol 
• 259137-72-9 Benzoic acid (2R,3S,4R)-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 
• 64332-71-4 4(R)-(6-chloro-9H-purin-9-yl)-2(R)-(hydroxymethyl)tetrahydrofuran-3(S)-ol 
• 140623-93-4 1,4-anhydro-2-deoxy-2-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>-D-arabinitol 

Relevant academic research and scientific papers

A new general synthesis of isomeric nucleosides

An efficient new method for the synthesis of isonucleosides is described. The key step in the synthesis was the direct coupling of purine and pyrimidine bases with the cyclic sulfate of a carbohydrate intermediate. This reaction proceeded with high regiospecificity and stereospecificity.

Synthesis and antiviral studies of unsaturated analogues of isomeric dideoxynucleosides

Novel isomeric dideoxynucleosides with unsaturation in the carbohydrate moiety have been synthesized. For example, isod4A was synthesized through a rearrangement reaction involving a cyclonucleoside. Support for the structures of both purine and pyrimidin