259199-37-6

Basic information

• Product Name: (E)-tert-butyl 4-[2-(6-cyano-2-naphthyl)vinyl]phenoxyacetate
• Synonyms: (E)-tert-butyl 4-[2-(6-cyano-2-naphthyl)vinyl]phenoxyacetate
• CAS NO: 259199-37-6
• Molecular Weight: 385.463
• Mol File: 259199-37-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-tert-butyl 4-[2-(6-cyano-2-naphthyl)vinyl]phenoxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-tert-butyl 4-[2-(6-cyano-2-naphthyl)vinyl]phenoxyacetate(259199-37-6)
• EPA Substance Registry System: (E)-tert-butyl 4-[2-(6-cyano-2-naphthyl)vinyl]phenoxyacetate(259199-37-6)

Safety Data

• Hazardous Substances Data: 259199-37-6(Hazardous Substances Data)

Upstream product

• 259199-34-3 6-[2-(4-methoxy-phenyl)-vinyl]-naphthalene-2-carbonitrile 
• 145369-29-5 trifluoromethanesulfonic acid 6-cyano-naphthalen-2-yl ester 
• 259199-33-2 2-cyano-6-vinylnaphthalene 
• 56358-62-4 6-formyl-2-naphthonitrile 
• 52927-22-7 6-cyano-2-naphthol 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 259199-36-5 (E)-2-cyano-6-[2-(4-hydroxyphenyl)vinyl]naphthalene 

Downstream Products

• 259199-39-8 tert-butyl 4-[2-(6-cyano-2-naphthyl)ethyl]phenoxyacetate 

Relevant articles and documents

Preparation and pharmacological evaluation of novel glycoprotein (Gp) IIb/IIIa antagonists. 1. The selection of naphthalene derivatives

The synthesis and design using molecular modeling techniques for non- peptide, low molecular weight novel fibrinogen receptor (glycoprotein IIb/IIIa: Gp IIb/IIIa) antagonists, is reported. We used a highly potent serine protease inhibitor, Nafamostat, having an amidinonaphthyl unit as the starting compound. The compounds 4-(6-amidino-2- naphthylaminocarbonyl)phenoxyacetic acid (5a) and 4-(6-amidino-2- naphthalenecarboxamido)phenoxyacetic acid (5b) inhibited adenosin-5'- diphospate (ADP)-induced aggregation of human platelet-rich plasma (PRP) with IC50 values of 0,05 and 0.07 μM, respectively, and had lost their ability to inhibit a variety of serine proteases, including thrombin, factor Xa, plasmin and trypsin.