2593-81-9

Basic information

• Product Name: N-Methyl-3-nitrophthalimide
• Synonyms: 2-Methyl-4-nitro-1H-isoindole-1,3(2H)-dione;N-Methyl-3-nitrophthalimide
• CAS NO: 2593-81-9
• Molecular Formula: C₉H₆N₂O₄
• Molecular Weight: 206.1549
• Mol File: 2593-81-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 373.2°Cat760mmHg
• Flash Point: 179.5°C
• Appearance: /
• Density: 1.533g/cm³
• Vapor Pressure: 9.11E-06mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: N-Methyl-3-nitrophthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-3-nitrophthalimide(2593-81-9)
• EPA Substance Registry System: N-Methyl-3-nitrophthalimide(2593-81-9)

Safety Data

• Hazardous Substances Data: 2593-81-9(Hazardous Substances Data)

Usage

General Description

N-Methyl-3-nitrophthalimide is a chemical compound with the molecular formula C9H6N2O4. It is a nitrophthalimide derivative that is used as a reagent for the determination of volatile amines in solution. N-Methyl-3-nitrophthalimide is a yellow crystalline solid with a high melting point and is sparingly soluble in water. It is primarily used in organic synthesis and as a reagent in the field of analytical chemistry. N-Methyl-3-nitrophthalimide is also known for its potential as a fluorescent probe for the detection of metal ions and as a precursor in the synthesis of various organic compounds. However, it is important to handle this chemical with care as it may have harmful effects if not used properly.

InChI:InChI=1/C9H6N2O4/c1-10-8(12)5-3-2-4-6(11(14)15)7(5)9(10)13/h2-4H,1H3

Upstream product

• 603-11-2 3-nitrophthalic acid 
• 74-89-5 methylamine 
• 5329-95-3 potassium 3-nitrophthalimide 
• 74-88-4 methyl iodide 
• 550-44-7 N-methylphthalimide 
• 603-62-3 4-nitro-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 2257-85-4 4-amino-2-methyl-1H-isoindole-1,3(2H)-dione 
• 98475-27-5 2-methyl-4-(phenylmethylthio)-1H-isoindole-1,3-(2H)-dione 
• 122993-59-3 4-amino-2,3-dihydro-2-methyl-1H-isoindole 
• 136860-34-9 2-<(2,3-Dihydro-2-methyl-1,3-dioxo-1H-isoindol-4-yl)oxy>benzoic Acid 

Relevant articles and documents

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors

Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers. Consequently porcupine inhibitors are thought to be promising oncology therapeutics. A high throughput screen against porcupine revealed several potent hits that were confirmed to be Wnt pathway inhibitors in secondary assays. We developed a pharmacophore model and used the putative bioactive conformation of a xanthine inhibitor for scaffold hopping. The resulting maleimide scaffold was optimized to subnanomolar potency while retaining good physical druglike properties. A preclinical development candidate was selected for which extensive in vitro and in vivo profiling is reported.

3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The present invention relates to 3-azabicyclo[3.1.0]hexane derivatives, which are useful as vanilloid receptor (VR) ligands, methods of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.