259802-91-0

Basic information

• Product Name: 1-[(5-chloroindol-1-phenylsulfonyl-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine
• Synonyms: 1-[(5-chloroindol-1-phenylsulfonyl-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine
• CAS NO: 259802-91-0
• Molecular Weight: 621.137
• Mol File: 259802-91-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[(5-chloroindol-1-phenylsulfonyl-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(5-chloroindol-1-phenylsulfonyl-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine(259802-91-0)
• EPA Substance Registry System: 1-[(5-chloroindol-1-phenylsulfonyl-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine(259802-91-0)

Safety Data

• Hazardous Substances Data: 259802-91-0(Hazardous Substances Data)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 78329-47-2 5-chloro-1-(phenylsulfonyl)-1H-indole 
• 17422-32-1 5-chloro-1H-indole 
• 249292-35-1 5-chloro-1-phenyl-sulfonylindole-2-sulfonyl chloride 
• 259807-33-5 1-(tert-butoxycarbonyl)-4-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]piperazine 
• 4385-76-6 4-(4-pyridinyl)benzoic acid 

Downstream Products

• 249292-02-2 1-(5-chloroindol-2-ylsulfonyl)4-[4-(pyridin-4-yl)benzoyl]piperazine 

Relevant articles and documents

Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites

Compound 7 was identified as the active metabolite of 6 by HPLC and mass spectral analysis. Modification of lead compound 7 by transformation of its N-oxide 6-6 biaryl ring system and fused aromatics produced a series of non-basic fXa inhibitors with excellent potency in anti-fXa and anticoagulant assays. The optimized compounds 73b and 75b showed sub to one digit micromolar anticoagulant activity (PTCT2). Particularly, anti-fXa activity was detected in plasma of rats orally administered with 1 mg/kg of compound 75b.