26002-57-3Relevant academic research and scientific papers
New benzimidazolequinones as trypanosomicidal agents
López-Lira, Claudia,Tapia, Ricardo A.,Herrera, Alejandra,Lapier, Michel,Maya, Juan D.,Soto-Delgado, Jorge,Oliver, Allen G.,Graham Lappin,Uriarte, Eugenio
, (2021)
Herein, the design and synthesis of new 2-phenyl(pyridinyl)benzimidazolequinones and their 5-phenoxy derivatives as potential anti-Trypanosoma cruzi agents are described. The compounds were evaluated in vitro against the epimastigotes and trypomastigote f
A pyridyl-benzimidazole based molecular luminescent turnstile
Godde, Bérangère,Ritaine, Dialia,Jouaiti, Abdelaziz,Mauro, Matteo,Hosseini, Mir Wais
, p. 7810 - 7815 (2018)
A molecular turnstile T1 based on a luminescent pyridyl-benzimidazole stator and a rotor containing a pyridyl coordinating site is designed and its multi-step synthesis is described. The turnstile T1 undergoes free rotation of the rotor around the stator.
Photocatalytic C-H Amination of Aromatics Overcoming Redox Potential Limitations
Ikarashi, Gun,Kano, Naokazu,Morofuji, Tatsuya
supporting information, p. 2822 - 2827 (2020/04/16)
We report the photocatalytic C-H amination of aromatics overcoming redox potential limitations. Radical cations of aromatic compounds are generated photocatalytically using Ru(phen)3(PF6)2, which has a reduction potential at a high oxidation state (Ered(RuIII/RuII) = +1.37 V vs SCE) lower than the oxidation potentials of aromatic substrates (Eox = +1.65 to +2.27 V vs SCE). The radical cations are trapped with pyridine to give N-arylpyridinium ions, which were converted to aromatic amines.
Electrochemical C-H amination: Synthesis of aromatic primary amines via N -arylpyridinium ions
Morofuji, Tatsuya,Shimizu, Akihiro,Yoshida, Jun-Ichi
supporting information, p. 5000 - 5003 (2013/05/22)
We have developed a new method for C-H amination of aromatic compounds based on electrochemical oxidation of aromatic compounds in the presence of pyridine followed by the reaction of the resulting N-arylpyridinium ions with an alkylamine. This new transformation serves as a powerful method for synthesizing aromatic primary amines from aromatic compounds without using metal catalysts and harsh chemical reagents. High chemoselectivity of the present method is demonstrated by C-H amination of aromatic compounds bearing a nitro group to give a key intermediate for the synthesis of VLA-4 antagonist.
The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase
Morin, Christophe,Besset, Tatiana,Moutet, Jean-Claude,Fayolle, Martine,Brueckner, Margit,Limosin, Daniele,Becker, Katja,Davioud-Charvet, Elisabeth
experimental part, p. 2731 - 2742 (2009/02/03)
Various aza-analogues of 1,4-naphthoquinone and menadione were prepared and tested as inhibitors and substrates of the plasmodial thioredoxin and glutathione reductases as well as the human glutathione reductase. The replacement of one to two carbons at the phenyl ring of the 1,4-naphthoquinone core by one to two nitrogen atoms led to an increased oxidant character of the molecules in accordance with both the redox potential values and the substrate efficiencies. Compared to the 1,4-naphthoquinone and menadione, the quinoline-5,8-dione 1 and both quinoxaline-5,8-diones 5 and 6 behaved as the most efficient subversive substrates of the three NADPH-dependent disulfide reductases tested. Modulation of these parameters was observed by alkylation of the aza-naphthoquinone core. The Royal Society of Chemistry.
