26040-75-5Relevant academic research and scientific papers
One-pot oxidative bromination – Esterification of aldehydes to 2-bromoesters using cerium (IV) ammonium nitrate and lithium bromide
Nikishin, Gennady I.,Kapustina, Nadezhda I.,Sokova, Lyubov L.,Bityukov, Oleg V.,Terent'ev, Alexander O.
, p. 352 - 354 (2017)
A two-step, one-pot reaction of aldehydes with the CAN/LiBr oxidation system under solvent-free conditions followed by the addition of methanol affords methyl α-bromocarboxylates. The oxidation of aldehydes with methanol using this system gives only methyl esters. A facile method, which does not require special equipment, was developed for the synthesis of 2-bromoesters from aliphatic aldehydes with carbon chain lengths of 5–10 atoms.
