26060-30-0

Basic information

• Product Name: 4-NITRO-THIOBENZAMIDE
• Synonyms: 4-nitrobenzothioamide;4-nitrobenzenecarbothioamide;p-Nitrothiobenzamide
• CAS NO: 26060-30-0
• Molecular Formula: C₇H₆N₂O₂S
• Molecular Weight: 182.2
• Mol File: 26060-30-0.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 345.3°C at 760 mmHg
• Flash Point: 162.6°C
• Appearance: /
• Density: 1.425g/cm³
• Vapor Pressure: 6.22E-05mmHg at 25°C
• Refractive Index: 1.692
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-NITRO-THIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-THIOBENZAMIDE(26060-30-0)
• EPA Substance Registry System: 4-NITRO-THIOBENZAMIDE(26060-30-0)

Safety Data

• Hazardous Substances Data: 26060-30-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2656, 1960 DOI: 10.1021/ja01495a078

InChI:InChI=1/C7H6N2O2S/c8-7(12)5-1-3-6(4-2-5)9(10)11/h1-4H,(H2,8,12)

Upstream product

• 13287-49-5 4-Nitro-benzylthiocyanat 
• 298-06-6 O,O-Diethyl hydrogen phosphorodithioate 
• 619-72-7 4-nitrobenzonitrile 
• 100-14-1 4-nitrobenzyl chloride 
• 619-80-7 4-nitrobenzamide 
• 19172-47-5 Lawessons reagent 
• 1129-37-9 4-nitrobenzaldehyde oxime 
• 555-16-8 4-nitrobenzaldehdye 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 1093215-86-1 2-(4-nitrophenyl)-4-butylthiazole 
• 1093215-92-9 potassium 2-iodo-5-methylbenzenesulfonate 
• 1093215-91-8 2-(4-nitrophenyl)-4-hexylthiazole 
• 1093215-83-8 2-(4-nitrophenyl)-4-phenylthiazole 
• 1239496-96-8 4-benzyl-5-butyl-2-(4-nitrophenyl)thiazole 
• 86814-28-0 3,5-bis(4-nitrophenyl)-1,2,4-thiadiazole 
• 2518-13-0 2-(4-nitrophenyl)-4,5-dihydro-1,3-thiazole 
• 1210761-69-5 methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate 
• 1448265-42-6 2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid 
• 17228-97-6 2-(4-nitrophenyl)-4-thiazolecarboxylic acid 
• 1287753-46-1 methyl 3-methyl-2-(2-(4-nitrophenyl)thiazole-4-carboxamido)butanoate 
• 1596358-19-8 3-ethyl-5-(4'-nitrophenyl)-1,2,4-thiadiazole 
• 1596358-10-9 5-(4'-aminophenyl)-3-ethyl-1,2,4-thiadiazole 
• 1596358-18-7 (E)-N-[1-(dimethylamino)propylidene]-4-nitrobenzenecarbothioamide 

Relevant articles and documents

Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides

A number of isosteres (oxadiazoles, thiadiazoles, tetrazoles and diazines) of benzocaine were prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed within each series, with 1,2,4-oxadiazole 3 (metHb% = 61.0 ± 3.6) and 1,3,4-oxadiazole 10 (metHb% = 52.4 ± 0.9) demonstrating the greatest activity. Of the 5 candidates (compounds 3, 10, 11, 13 and 23) evaluated in vivo, failure to induce a lethal end-point at doses of 120 mg/kg was observed in all cases. Inadequate metabolic stability, particularly towards hepatic enzymes such as the CYPs, was postulated as one reason for their failure.

Agonists for the adenosine A1 receptor with tunable residence time. a case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines

We report the synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A 1 receptor (hA1AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the target receptor. They show a very diverse range of kinetic profiles (from 1 min (compound 52) to 1 h (compound 43)), and their structure-affinity relationships (SAR) and structure-kinetics relationships (SKR) were established. When put in perspective with the increasing importance of binding kinetics in drug discovery, these results bring new evidence of the consequences of affinity-only driven selection of drug candidates, that is, the potential elimination of slightly less active compounds that may display preferable binding kinetics.

Sulfonic acid functionalized nano Γ-Al 2O 3: A new, efficient, and reusable catalyst for synthesis of thioamides

Sulfonic acid functionalized nano γ-Al2O3 is easily prepared by the reaction of nano γ-Al2O3 with 1,3-propane sulfone. This reagent can be used as an eficient catalyst for the synthesis of thioamides. This new method consistently has the advantages of excellent yields and short reaction times. Further, the catalyst can be recovered for several times.