26132-51-4

Basic information

• Product Name: 4-(DIFLUOROMETHYL)-1-FLUOROBENZENE
• Synonyms: 4-(DIFLUOROMETHYL)-1-FLUOROBENZENE;BENZENE, 1-(DIFLUOROMETHYL)-4-FLUORO-
• CAS NO: 26132-51-4
• Molecular Formula: C₇H₅F₃
• Molecular Weight: 146.11
• Mol File: 26132-51-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 127.9±30.0 °C(Predicted)
• Appearance: /
• Density: 1.201±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-(DIFLUOROMETHYL)-1-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(DIFLUOROMETHYL)-1-FLUOROBENZENE(26132-51-4)
• EPA Substance Registry System: 4-(DIFLUOROMETHYL)-1-FLUOROBENZENE(26132-51-4)

Safety Data

• Hazardous Substances Data: 26132-51-4(Hazardous Substances Data)

Usage

Description

4-(DIFLUOROMETHYL)-1-FLUOROBENZENE is a fluorinated organic compound with the molecular formula C6H4F2 and a molecular weight of 126.09 g/mol. It is a colorless liquid with a faint aromatic odor, insoluble in water but soluble in organic solvents.
Used in Pharmaceutical Industry:
4-(DIFLUOROMETHYL)-1-FLUOROBENZENE is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Agrochemical Industry:
4-(DIFLUOROMETHYL)-1-FLUOROBENZENE is used as a building block for the synthesis of agrochemicals, aiding in the creation of more effective and targeted pesticides and other agricultural chemicals.
Used in Specialty Chemicals Industry:
4-(DIFLUOROMETHYL)-1-FLUOROBENZENE is used as a building block for the synthesis of specialty chemicals, which can be utilized in various applications such as coatings, adhesives, and other industrial products.
Used in Organic Reactions:
4-(DIFLUOROMETHYL)-1-FLUOROBENZENE is used as a reagent in organic reactions, facilitating specific chemical transformations and contributing to the synthesis of complex organic molecules.
Used in Chemical Processes:
4-(DIFLUOROMETHYL)-1-FLUOROBENZENE is used as a solvent in various chemical processes, helping to dissolve and process other chemicals in a controlled and efficient manner.
It is important to handle 4-(DIFLUOROMETHYL)-1-FLUOROBENZENE with care, as it may be harmful if inhaled, swallowed, or comes into contact with the skin.

Upstream product

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• 225916-39-2 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
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Downstream Products

• 1022157-90-9 5-(difluoromethyl)-2-fluorobenzaldehyde 
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Relevant articles and documents

The Difluoromethylated Organogold(III) Complex cis-[Au(PCy3)(4-F-C6H4)(CF2H)(Cl)]: Preparation, Characterization, and Its C(sp2)-CF2H Reductive Elimination

The preparation of the difluoromethylated organogold(III) complex cis-[Au(PCy3)(4-F-C6H4)(CF2H)(Cl)] (3) and its Ar-CF2H reductive elimination are described. In the presence of 1.0 equiv of AgSbF6 or AgPF6, compound 3 underwent a quantitative Ar-CF2H reductive elimination in less than 1.0 min at 25 °C, while the lack of silver salt resulted in Ar-CF2H reductive elimination from complex 3 in 1,1,2,2-tetrachloroethane (CCl2HCCl2H) after 80 min at 115 °C to afford the elimination product p-F-PhCF2H (4) and (Cy3P)Au(Cl) in quantitative yields. On the basis of the mechanistic studies of the kinetics of the reaction and DFT calculation, a concerted Ar-CF2H bond-forming pathway for the Ar-CF2H reductive elimination from organogold(III) complex 3 is proposed.

Iron-Catalyzed Fluoroalkylation of Arylborates with Sulfone Reagents: Beyond the Limitation of Reduction Potential

The iron-catalyzed alkyl–aryl coupling reaction between sulfones and arylboron compounds has remained a challenge. We report the first iron-catalyzed radical difluoroalkylation of arylborates with N-heteroaryl sulfones. The coordination between the iron catalyst and the nitrogen atom of N-heteroaryl sulfones was identified to be important in overcoming the reduction potential limitation of sulfones in the intermolecular single-electron-transfer process, which enables both fluoroalkyl N-heteroaryl sulfones (with relatively high reduction potentials) and nonfluorinated alkyl N-heteroaryl sulfones (with low reduction potentials) to serve as powerful alkylation reagents.

Metallaphotoredox Difluoromethylation of Aryl Bromides

Herein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl-radical-mediated halogen abstraction. The merger of this fluoroalkyl electrophile activation pathway with a dual nickel/photoredox catalytic platform enables the difluoromethylation of a diverse array of aryl and heteroaryl bromides under mild conditions. The utility of this procedure is showcased in the late-stage functionalization of several drug analogues.